DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park J. | ko |
dc.contributor.author | Kwon D. | ko |
dc.contributor.author | Choi, Chulhee | ko |
dc.contributor.author | Oh J.-W. | ko |
dc.contributor.author | Benveniste E.N. | ko |
dc.date.accessioned | 2013-03-04T14:48:02Z | - |
dc.date.available | 2013-03-04T14:48:02Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | JOURNAL OF NEUROCHEMISTRY, v.84, no.6, pp.1266 - 1274 | - |
dc.identifier.issn | 0022-3042 | - |
dc.identifier.uri | http://hdl.handle.net/10203/82990 | - |
dc.description.abstract | Chloroquine, an antimalarial lysosomotropic base, is known for its anti-inflammatory effects and therefore used for treatment of autoimmune diseases. Given its anti-inflammatory effects, it has been under clinical trials to modify neurodegenerative processes. In this study, we examined whether chloroquine has an anti-inflammatory effect in the CNS by determining the in vitro effects of chloroquine on LPS-induced expression of cytokines by glial cells. We observed that (i) chloroquine augmented LPS-induced expression of pro-inflammatory cytokines such as lymphotoxin (LT)-beta, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1alpha, IL-1beta and IL-6 in human astroglial cells, while the same treatment suppressed LPS-induced expression of cytokines in monocytic and microglial cells; (ii) chloroquine alone induced expression of pro-inflammatory cytokines in a dose- and time-dependent manner in astroglial cells; (iii) other lysosomotropic agents such as ammonium chloride and bafilomycin A(1) had minimal effects on cytokine expression; and (iv) chloroquine induced the activation of nuclear factor-kappa B in astroglial cells, which is a required component of chloroquine induction of cytokines. These results suggest that chloroquine may evoke either anti- or pro-inflammatory responses in the CNS depending on the cellular context. | - |
dc.language | English | - |
dc.publisher | BLACKWELL PUBLISHING LTD | - |
dc.subject | TUMOR-NECROSIS-FACTOR | - |
dc.subject | SPINAL-CORD INJURY | - |
dc.subject | TRANSGENIC MICE | - |
dc.subject | FACTOR-ALPHA | - |
dc.subject | TNF-ALPHA | - |
dc.subject | SIGNALING PATHWAYS | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | PROTEIN-KINASE | - |
dc.subject | T-CELLS | - |
dc.subject | ASTROCYTES | - |
dc.title | Chloroquine induces activation of nuclear factor-kappa B and subsequent expression of pro-inflammatory cytokines by human astroglial cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000181331300005 | - |
dc.identifier.scopusid | 2-s2.0-0037343964 | - |
dc.type.rims | ART | - |
dc.citation.volume | 84 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 1266 | - |
dc.citation.endingpage | 1274 | - |
dc.citation.publicationname | JOURNAL OF NEUROCHEMISTRY | - |
dc.identifier.doi | 10.1046/j.1471-4159.2003.01623.x | - |
dc.contributor.localauthor | Choi, Chulhee | - |
dc.contributor.nonIdAuthor | Park J. | - |
dc.contributor.nonIdAuthor | Kwon D. | - |
dc.contributor.nonIdAuthor | Oh J.-W. | - |
dc.contributor.nonIdAuthor | Benveniste E.N. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | cytokines | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | neuroimmunology | - |
dc.subject.keywordAuthor | transcription factors | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | SPINAL-CORD INJURY | - |
dc.subject.keywordPlus | TRANSGENIC MICE | - |
dc.subject.keywordPlus | FACTOR-ALPHA | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | ASTROCYTES | - |
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