DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, H.S. | ko |
dc.contributor.author | Kim, D.I. | ko |
dc.contributor.author | Lee, B.I. | ko |
dc.contributor.author | Jeong, E.K. | ko |
dc.contributor.author | Choi, Chulhee | ko |
dc.contributor.author | Lee, J.D. | ko |
dc.contributor.author | Yoon, P.H. | ko |
dc.contributor.author | Kim, E.J. | ko |
dc.contributor.author | Kim, S.H. | ko |
dc.contributor.author | Yoon, Y.K. | ko |
dc.date.accessioned | 2013-03-04T14:45:32Z | - |
dc.date.available | 2013-03-04T14:45:32Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | YONSEI MEDICAL JOURNAL, v.42, no.1, pp.128 - 133 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | http://hdl.handle.net/10203/82986 | - |
dc.description.abstract | We report the clinical and MR manifestations of an 18 year-old girl with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome. Recurrent status epilepticus caused reversible cytotoxic edema on diffusion-weighted images (DWI). Initial and one month follow-up MR spectroscopy, after seizure control, showed some discrepancies in the ratio of metabolites. N-acetylaspartate (NAA) partially recovered (NAA/creatine (Cr) ratio: 1.27 -->1.84). This was because of a normalization of decreased NAA due to cellular dysfunction as a result of status epilepticus. A low ratio of NAA/Cr due to abnormal mitochondria remained in the decreased state. Reversible NAA/Cr ratios in the acute lesion suggested that NAA reflects the neuronal function as well as the level of neuronal structural damage. The altered NAA/Cr ratio better correlated with the abnormal signal intensity area of T2-weighted images (T2WI) and DWI than the lactate (Lac)/Cr ratio. With conservative treatment with anti-epileptics not accompanied by coenzyme Q or sodium dichloroacetate, lactate persistently increased (Lac/Cr ratio: 1.01 -->1.21) because of the continued production of lactate in cells with respiratory deficiency, which is the main pathology of MELAS. | - |
dc.language | English | - |
dc.publisher | YONSEI UNIV COLLEGE MEDICINE | - |
dc.subject | MAGNETIC-RESONANCE SPECTROSCOPY | - |
dc.subject | INDUCED SEIZURES | - |
dc.subject | COMBINED H-1 | - |
dc.subject | MITOCHONDRIAL | - |
dc.subject | ABNORMALITIES | - |
dc.title | Diffusion-weighted image and MR spectroscopic analysis of a case of MELAS with repeated attacks | - |
dc.type | Article | - |
dc.identifier.wosid | 000167692500016 | - |
dc.identifier.scopusid | 2-s2.0-0035259363 | - |
dc.type.rims | ART | - |
dc.citation.volume | 42 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 128 | - |
dc.citation.endingpage | 133 | - |
dc.citation.publicationname | YONSEI MEDICAL JOURNAL | - |
dc.contributor.localauthor | Choi, Chulhee | - |
dc.contributor.nonIdAuthor | Kim, H.S. | - |
dc.contributor.nonIdAuthor | Kim, D.I. | - |
dc.contributor.nonIdAuthor | Lee, B.I. | - |
dc.contributor.nonIdAuthor | Jeong, E.K. | - |
dc.contributor.nonIdAuthor | Lee, J.D. | - |
dc.contributor.nonIdAuthor | Yoon, P.H. | - |
dc.contributor.nonIdAuthor | Kim, E.J. | - |
dc.contributor.nonIdAuthor | Kim, S.H. | - |
dc.contributor.nonIdAuthor | Yoon, Y.K. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | magnetic resonance imaging | - |
dc.subject.keywordAuthor | diffusion study | - |
dc.subject.keywordAuthor | spectroscopy | - |
dc.subject.keywordAuthor | MELAS | - |
dc.subject.keywordAuthor | brain metabolism | - |
dc.subject.keywordPlus | MAGNETIC-RESONANCE SPECTROSCOPY | - |
dc.subject.keywordPlus | INDUCED SEIZURES | - |
dc.subject.keywordPlus | COMBINED H-1 | - |
dc.subject.keywordPlus | MITOCHONDRIAL | - |
dc.subject.keywordPlus | ABNORMALITIES | - |
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