DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, WK | ko |
dc.contributor.author | Bolser, DM | ko |
dc.contributor.author | Park, Jong H. | ko |
dc.date.accessioned | 2013-03-04T14:14:21Z | - |
dc.date.available | 2013-03-04T14:14:21Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2004-05 | - |
dc.identifier.citation | BIOINFORMATICS, v.20, no.7, pp.1138 - 1150 | - |
dc.identifier.issn | 1367-4803 | - |
dc.identifier.uri | http://hdl.handle.net/10203/82910 | - |
dc.description.abstract | Motivation: Interacting pairs of proteins should co-evolve to maintain functional and structural complementarity. Consequently, such a pair of protein families shows similarity between their phylogenetic trees. Although the tendency of co-evolution has been known for various ligand-receptor pairs, it has not been studied systematically in the widest possible scope. We investigated the degree of co-evolution for more than 900 family pairs in a global protein structural interactome map (PSIMAP-a map of all the structural domain-domain interactions in the PDB). Results: There was significant correlation in 45% of the total SCOPs Family level pairs, rising to 78% in 454 reliable family interactions. Expectedly, the intra-molecular interactions between protein families showed stronger co-evolution than inter-molecular interactions. However, both types of interaction have a fundamentally similar pattern of co-evolution except for cases where different interfaces are involved. These results validate the use of co-evolution analysis with predictive methods such as PSIMAP to improve the accuracy of prediction based on 'homologous interaction'. The tendency of co-evolution enabled a nearly 5-fold enrichment in the identification of true interactions among the potential interlogues in PSIMAP. The estimated sensitivity was 79.2%, and the specificity was 78.6%. | - |
dc.language | English | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.subject | LIGAND-RECEPTOR PAIRS | - |
dc.subject | SACCHAROMYCES-CEREVISIAE | - |
dc.subject | YEAST | - |
dc.subject | CONSERVATION | - |
dc.subject | SEQUENCES | - |
dc.subject | COMPLEXES | - |
dc.subject | SITES | - |
dc.subject | TREES | - |
dc.title | Large-scale co-evolution analysis of protein structural interlogues using the global protein structural interactome map (PSIMAP) | - |
dc.type | Article | - |
dc.identifier.wosid | 000221139700017 | - |
dc.identifier.scopusid | 2-s2.0-2442646432 | - |
dc.type.rims | ART | - |
dc.citation.volume | 20 | - |
dc.citation.issue | 7 | - |
dc.citation.beginningpage | 1138 | - |
dc.citation.endingpage | 1150 | - |
dc.citation.publicationname | BIOINFORMATICS | - |
dc.identifier.doi | 10.1093/bioinformatics/bth053 | - |
dc.contributor.localauthor | Park, Jong H. | - |
dc.contributor.nonIdAuthor | Kim, WK | - |
dc.contributor.nonIdAuthor | Bolser, DM | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | LIGAND-RECEPTOR PAIRS | - |
dc.subject.keywordPlus | SACCHAROMYCES-CEREVISIAE | - |
dc.subject.keywordPlus | YEAST | - |
dc.subject.keywordPlus | CONSERVATION | - |
dc.subject.keywordPlus | SEQUENCES | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordPlus | SITES | - |
dc.subject.keywordPlus | TREES | - |
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