DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, JY | ko |
dc.contributor.author | Park, SJ | ko |
dc.contributor.author | Shim, KY | ko |
dc.contributor.author | Lee, KJ | ko |
dc.contributor.author | Kim, YB | ko |
dc.contributor.author | Kim, Yong Hae | ko |
dc.contributor.author | Kim, SK | ko |
dc.date.accessioned | 2013-03-04T13:26:51Z | - |
dc.date.available | 2013-03-04T13:26:51Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | PHARMACOLOGICAL RESEARCH, v.50, no.2, pp.201 - 207 | - |
dc.identifier.issn | 1043-6618 | - |
dc.identifier.uri | http://hdl.handle.net/10203/82778 | - |
dc.description.abstract | Echinomycin, in typical DNA minor groove binder, had comparable efficacy compared to 5-FU in the phase 11 trail of colon cancer treatment. To improve echinomycin's drawback (hydrophobicity, toxicity), we synthesized the YK-2000 series (echinomycin analogues). Among these, YK-2000 had the best in vitro cytotoxicity on six different human solid cancer cell lines. Echinomycin and YK-2000 were enabled to induce the apoptosis on the HT-29 colorectal cancer cell line. The hypothesis that apoptosis in the HT-29 cell was triggered by echinomycin and YK-2000 were supported through DNA laddering, poly-(ADP-ribose) polymerase (PARP) cleavage, and flow cytometric analysis. In order to explore the signaling pathway of echinomycin and YK-2000, we examined the phosphorylation of extracellular signal-regulated kinase1/2 (ERK1/2), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and p38 MAP kinase. However, what the mechanism of cancer cell death would be induced by echinomycin and YK-2000 is unknown. Here, we present some evidence that one of the major apoptotic signaling pathways induced by echinomycin and YK-2000 is possibly the MAP kinases pathway in HT-29 human colon cancer cells. (C) 2004 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD | - |
dc.subject | MURINE LEUKEMIA-CELLS | - |
dc.subject | POLY(ADP-RIBOSE) POLYMERASE | - |
dc.subject | PROTEIN-KINASES | - |
dc.subject | CANCER-CHEMOTHERAPY | - |
dc.subject | DNA-DAMAGE | - |
dc.subject | P38 | - |
dc.subject | CLEAVAGE | - |
dc.subject | BINDING | - |
dc.subject | JNK | - |
dc.subject | JNK/SAPK | - |
dc.title | Echinomycin and a novel analogue induce apoptosis of HT-29 cells via the activation of MAP kinases pathway | - |
dc.type | Article | - |
dc.identifier.wosid | 000222693100013 | - |
dc.identifier.scopusid | 2-s2.0-2942625973 | - |
dc.type.rims | ART | - |
dc.citation.volume | 50 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 201 | - |
dc.citation.endingpage | 207 | - |
dc.citation.publicationname | PHARMACOLOGICAL RESEARCH | - |
dc.identifier.doi | 10.1016/j.phrs.2004.01.005 | - |
dc.contributor.nonIdAuthor | Park, JY | - |
dc.contributor.nonIdAuthor | Park, SJ | - |
dc.contributor.nonIdAuthor | Shim, KY | - |
dc.contributor.nonIdAuthor | Lee, KJ | - |
dc.contributor.nonIdAuthor | Kim, YB | - |
dc.contributor.nonIdAuthor | Kim, SK | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | echinomycin | - |
dc.subject.keywordAuthor | YK-2000 | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | MAP kinases | - |
dc.subject.keywordAuthor | HT-291 | - |
dc.subject.keywordPlus | MURINE LEUKEMIA-CELLS | - |
dc.subject.keywordPlus | POLY(ADP-RIBOSE) POLYMERASE | - |
dc.subject.keywordPlus | PROTEIN-KINASES | - |
dc.subject.keywordPlus | CANCER-CHEMOTHERAPY | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | P38 | - |
dc.subject.keywordPlus | CLEAVAGE | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | JNK | - |
dc.subject.keywordPlus | JNK/SAPK | - |
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