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College of Engineering(공과대학)Dept. of Nuclear and Quantum Engineering(원자력및양자공학과)NE-Journal Papers(저널논문)

Design and synthesis of 7-hydroxy-1H-benzoimidazole derivatives as novel inhibitors of glycogen synthase kinase-3 beta

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dc.contributor.authorShin, Dongkyuko
dc.contributor.authorLee, Seung-Chulko
dc.contributor.authorHeo, Yong-Seokko
dc.contributor.authorLee, Woon-Youngko
dc.contributor.authorCho, Yong-Soonko
dc.contributor.authorKim, Yong Eunko
dc.contributor.authorHyun, Young-Lanko
dc.contributor.authorCho, Joong Myungko
dc.contributor.authorLee, Yoon Supko
dc.contributor.authorRo, Seongguko
dc.date.accessioned2009-01-06T06:41:02Z-
dc.date.available2009-01-06T06:41:02Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2007-10-
dc.identifier.citationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.17, no.20, pp.5686 - 5689-
dc.identifier.issn0960-894X-
dc.identifier.urihttp://hdl.handle.net/10203/8225-
dc.description.abstractA hydroxy functional group was introduced as the hydrogen bond donor and acceptor at the hinge region of protein kinase in order to develop novel ATP-competitive inhibitors. Several derivatives of 7-hydroxyl-1H-benzoimidazole were designed as inhibitors of glycogen synthase kinase-3 beta with the help of ab initio calculations and a docking study. Enzymatic assay and an X-ray complex study showed that these designed compounds were highly potent ATP-competitive inhibitors. (c) 2007 Elsevier Ltd. All rights reserved.-
dc.description.sponsorshipThis work was partially supported by Yuyu, Inc. as well as by the National Research Laboratory Program of MOST (Ministry of Science and Technology) and MOCIE(Ministry of Commerce, Industry and Energy) of Korea and Medium-term Strategic Technology Development Program of MOICE.en
dc.languageEnglish-
dc.language.isoen_USen
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectSKELETAL-MUSCLE-
dc.subjectPROTEIN-KINASE-
dc.subjectMECHANISM-
dc.subjectBETA-
dc.subjectMICE-
dc.titleDesign and synthesis of 7-hydroxy-1H-benzoimidazole derivatives as novel inhibitors of glycogen synthase kinase-3 beta-
dc.typeArticle-
dc.identifier.wosid000250287600040-
dc.identifier.scopusid2-s2.0-34548608549-
dc.type.rimsART-
dc.citation.volume17-
dc.citation.issue20-
dc.citation.beginningpage5686-
dc.citation.endingpage5689-
dc.citation.publicationnameBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.identifier.doi10.1016/j.bmcl.2007.07.056-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorLee, Yoon Sup-
dc.contributor.nonIdAuthorShin, Dongkyu-
dc.contributor.nonIdAuthorLee, Seung-Chul-
dc.contributor.nonIdAuthorHeo, Yong-Seok-
dc.contributor.nonIdAuthorLee, Woon-Young-
dc.contributor.nonIdAuthorCho, Yong-Soon-
dc.contributor.nonIdAuthorKim, Yong Eun-
dc.contributor.nonIdAuthorHyun, Young-Lan-
dc.contributor.nonIdAuthorCho, Joong Myung-
dc.contributor.nonIdAuthorRo, Seonggu-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorkinase inhibitor-
dc.subject.keywordAuthordrug design-
dc.subject.keywordAuthorglycogen synthase kinase-
dc.subject.keywordAuthorGSK-
dc.subject.keywordAuthor7-hydroxy-1H-benzoimidazole-
dc.subject.keywordPlusSKELETAL-MUSCLE-
dc.subject.keywordPlusPROTEIN-KINASE-
dc.subject.keywordPlusMECHANISM-
dc.subject.keywordPlusBETA-
dc.subject.keywordPlusMICE-
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