DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, JS | ko |
dc.contributor.author | Jeon, YJ | ko |
dc.contributor.author | Park, SK | ko |
dc.contributor.author | Yang, Kyu Hwan | ko |
dc.contributor.author | Kim, HM | ko |
dc.date.accessioned | 2013-03-04T07:56:07Z | - |
dc.date.available | 2013-03-04T07:56:07Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2004-01 | - |
dc.identifier.citation | BIOCHEMICAL PHARMACOLOGY, v.67, no.1, pp.175 - 181 | - |
dc.identifier.issn | 0006-2952 | - |
dc.identifier.uri | http://hdl.handle.net/10203/82077 | - |
dc.description.abstract | Silymarin is known to have hepatoprotective and anticarcinogenic effects. Recently, anti-inflammatory effect of silymarin is attracting an increasing attention, but the mechanism of this effect is not fully understood. Here, we report that silymarin protected mice against lipopolysaccharide (LPS)-induced sepsis. In this model of sepsis, silymarin improved the rate of survival of LPS-treated mice from 6 to 38%. To further investigate the mechanism responsible for anti-septic effect of silymarin, we examined the inhibitory effect of silymarin on interleukin-1beta (IL-1beta) and prostaglandin E2 (PGE2) production in macrophages. Silymarin dose-dependently suppressed the LPS-induced production of IL-10 and PGE2 in isolated mouse peritoneal macrophages and RAW 264.7 cells. Consistent with these results, the mRNA expression of IL-1beta and cyclooxygenase-2 was also completely blocked by silymarin in LPS-stimulated RAW 264.7 cells. Moreover, the LPS-induced DNA binding activity of nuclear factor-kappaB/Rel was also inhibited by silymarin in RAW 264.7 cells. Taken together, these results demonstrate that silymarin has a protective effect against endotoxin-induced sepsis, and suggest that this is mediated, at least in part, by the inhibitory effect of silymarin on the production of IL-10 and PGE2. (C) 2003 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | NITRIC-OXIDE SYNTHASE | - |
dc.subject | SEPTIC SHOCK | - |
dc.subject | FLAVONOID ANTIOXIDANT | - |
dc.subject | RECEPTOR ANTAGONIST | - |
dc.subject | ACTIVE CONSTITUENT | - |
dc.subject | PROTEIN-KINASE | - |
dc.subject | MESSENGER-RNA | - |
dc.subject | MACROPHAGES | - |
dc.subject | EXPRESSION | - |
dc.title | Protection against lipopolysaccharide-induced sepsis and inhibition of interleukin-1 beta and prostaglandin E2 synthesis by silymarin | - |
dc.type | Article | - |
dc.identifier.wosid | 000187573100017 | - |
dc.identifier.scopusid | 2-s2.0-0344687228 | - |
dc.type.rims | ART | - |
dc.citation.volume | 67 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 175 | - |
dc.citation.endingpage | 181 | - |
dc.citation.publicationname | BIOCHEMICAL PHARMACOLOGY | - |
dc.identifier.doi | 10.1016/j.bcp.2003.08.032 | - |
dc.contributor.nonIdAuthor | Kang, JS | - |
dc.contributor.nonIdAuthor | Jeon, YJ | - |
dc.contributor.nonIdAuthor | Park, SK | - |
dc.contributor.nonIdAuthor | Kim, HM | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | silymarin | - |
dc.subject.keywordAuthor | interleukin-1 beta | - |
dc.subject.keywordAuthor | prostaglandin E2 | - |
dc.subject.keywordAuthor | cyclooxygenase-2 | - |
dc.subject.keywordAuthor | NF-beta B/Rel | - |
dc.subject.keywordAuthor | sepsis | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | SEPTIC SHOCK | - |
dc.subject.keywordPlus | FLAVONOID ANTIOXIDANT | - |
dc.subject.keywordPlus | RECEPTOR ANTAGONIST | - |
dc.subject.keywordPlus | ACTIVE CONSTITUENT | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | EXPRESSION | - |
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