Dna2 requirement for normal reproduction of Caenorhabditis elegans is temperature-dependent

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dc.contributor.authorLee, KHko
dc.contributor.authorLee, MHko
dc.contributor.authorLee, THko
dc.contributor.authorHan, JWko
dc.contributor.authorPark, YJko
dc.contributor.authorAhnn, Jko
dc.contributor.authorSeo, Yeon-Sooko
dc.contributor.authorKoo, HSko
dc.date.accessioned2013-03-04T01:34:23Z-
dc.date.available2013-03-04T01:34:23Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2003-02-
dc.identifier.citationMOLECULES AND CELLS, v.15, pp.81 - 86-
dc.identifier.issn1016-8478-
dc.identifier.urihttp://hdl.handle.net/10203/81327-
dc.description.abstractTo determine the function of Dna2 in a multicellular organism, the Caenorhabditis elegans Dna2 expression was probed and deletion mutant phenotypes were analyzed. Dna2 was localized to the nuclei of C. elegans oocytes and early embryos by immunostaining or green fluorescent protein-tagging. A homozygous dna2 deletion mutant showed a reduced brood size and embryonic lethality, and the phenotypes greatly depended on growth temperature and aggravated in the succeeding generation. The mutant embryos also showed delayed cell divisions, which together with temperature-dependence of the mutant phenotypes supported the well-conserved role of Dna2 in DNA replication.-
dc.languageEnglish-
dc.publisherKOREAN SOC MOLECULAR & CELLULAR BIOLOGY-
dc.subjectSINGLE-STRANDED-DNA-
dc.subjectESSENTIAL IN-VIVO-
dc.subjectENDONUCLEASE ACTIVITY-
dc.subjectGERMLINE DEVELOPMENT-
dc.subjectC-ELEGANS-
dc.subjectREPLICATION-
dc.subjectHELICASE-
dc.subjectPROTEIN-
dc.subjectENCODES-
dc.subjectMUTATIONS-
dc.titleDna2 requirement for normal reproduction of Caenorhabditis elegans is temperature-dependent-
dc.typeArticle-
dc.identifier.wosid000181333400012-
dc.identifier.scopusid2-s2.0-0037900132-
dc.type.rimsART-
dc.citation.volume15-
dc.citation.beginningpage81-
dc.citation.endingpage86-
dc.citation.publicationnameMOLECULES AND CELLS-
dc.contributor.localauthorSeo, Yeon-Soo-
dc.contributor.nonIdAuthorLee, KH-
dc.contributor.nonIdAuthorLee, MH-
dc.contributor.nonIdAuthorLee, TH-
dc.contributor.nonIdAuthorHan, JW-
dc.contributor.nonIdAuthorPark, YJ-
dc.contributor.nonIdAuthorAhnn, J-
dc.contributor.nonIdAuthorKoo, HS-
dc.type.journalArticleArticle-
dc.subject.keywordAuthordna2 endonuclease/helicase-
dc.subject.keywordAuthorembryonic lethality-
dc.subject.keywordAuthorexpressional localization-
dc.subject.keywordAuthorreplication-
dc.subject.keywordPlusSINGLE-STRANDED-DNA-
dc.subject.keywordPlusESSENTIAL IN-VIVO-
dc.subject.keywordPlusENDONUCLEASE ACTIVITY-
dc.subject.keywordPlusGERMLINE DEVELOPMENT-
dc.subject.keywordPlusC-ELEGANS-
dc.subject.keywordPlusREPLICATION-
dc.subject.keywordPlusHELICASE-
dc.subject.keywordPlusPROTEIN-
dc.subject.keywordPlusENCODES-
dc.subject.keywordPlusMUTATIONS-
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