DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, W | ko |
dc.contributor.author | Moon, SO | ko |
dc.contributor.author | Sung, MJ | ko |
dc.contributor.author | Kim, SH | ko |
dc.contributor.author | Lee, S | ko |
dc.contributor.author | Kim, HJ | ko |
dc.contributor.author | Koh, Gou Young | ko |
dc.contributor.author | Park, SK | ko |
dc.date.accessioned | 2013-03-03T23:52:51Z | - |
dc.date.available | 2013-03-03T23:52:51Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2002-12 | - |
dc.identifier.citation | APOPTOSIS, v.7, pp.527 - 536 | - |
dc.identifier.issn | 1360-8185 | - |
dc.identifier.uri | http://hdl.handle.net/10203/80964 | - |
dc.description.abstract | Mannitol therapy is widely used for reducing brain edema, and ischemic brain swelling. However, mannitol at clinical concentrations induces apoptosis in endothelial cells. Because apoptosis may be a pathogenic mechanism in vascular injury, antiapoptotic agents may have a protective role in mannitol-induced apoptosis. In this study, we examined whether adrenomedullin (AM) prevents mannitol-induced apoptosis and also evaluated the associated signaling pathway of AM in human umbilical vein endothelial cells. AM prevented mannitol-induced apoptosis in a dose-dependent manner. Pretreatment with wortmannin blocked the AM-induced antiapoptotic effect. AM stimulated Akt at Ser473, and wortmannin inhibited the AM-induced Akt phosphorylation. These findings indicate that phosphatidylinositol 3'-kinase/Akt pathway transmits the survival signal from AM. The potency of antiapoptotic effect of AM is stronger than that of vascular endothelial growth factor and angiopoietin-1 in mannitol-induced apoptosis. AM can have a protective role not only in umbilical vein, but also in pulmonary, coronary, and aortic endothelial cells. These findings indicate that AM has a potent protective role in mannitol-induced apoptosis, through phosphatidylinositol 3'-kinase/Akt pathway. Therefore, pretreatment with AM might help to maintain normal endothelial integrity during systemic mannitol therapy. | - |
dc.language | English | - |
dc.publisher | SPRINGER | - |
dc.subject | STIMULATES DNA-SYNTHESIS | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | SURVIVAL FACTOR | - |
dc.subject | GROWTH-FACTOR | - |
dc.subject | ANGIOPOIETIN-1 | - |
dc.subject | PROLIFERATION | - |
dc.subject | ACTIVATION | - |
dc.subject | RECEPTOR | - |
dc.subject | PATHWAYS | - |
dc.subject | CAMP | - |
dc.title | Protective effect of adrenomedullin in mannitol-induced apoptosis | - |
dc.type | Article | - |
dc.identifier.wosid | 000178618900007 | - |
dc.identifier.scopusid | 2-s2.0-0036889209 | - |
dc.type.rims | ART | - |
dc.citation.volume | 7 | - |
dc.citation.beginningpage | 527 | - |
dc.citation.endingpage | 536 | - |
dc.citation.publicationname | APOPTOSIS | - |
dc.identifier.doi | 10.1023/A:1020695110648 | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.nonIdAuthor | Kim, W | - |
dc.contributor.nonIdAuthor | Moon, SO | - |
dc.contributor.nonIdAuthor | Sung, MJ | - |
dc.contributor.nonIdAuthor | Kim, SH | - |
dc.contributor.nonIdAuthor | Lee, S | - |
dc.contributor.nonIdAuthor | Kim, HJ | - |
dc.contributor.nonIdAuthor | Park, SK | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | adrenomedullin | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | endothelial cells | - |
dc.subject.keywordAuthor | mannitol | - |
dc.subject.keywordPlus | STIMULATES DNA-SYNTHESIS | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | SURVIVAL FACTOR | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | ANGIOPOIETIN-1 | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | CAMP | - |
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