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College of Engineering(공과대학)Dept. of Nuclear and Quantum Engineering(원자력및양자공학과)NE-Journal Papers(저널논문)

Synthesis and biological activity of new quinoxaline antibiotics of echinomycin analogues

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dc.contributor.authorKim Y.B.ko
dc.contributor.authorKim, Yong Haeko
dc.contributor.authorPark J.Y.ko
dc.contributor.authorKim S.K.ko
dc.date.accessioned2013-03-03T23:20:25Z-
dc.date.available2013-03-03T23:20:25Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2004-
dc.identifier.citationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.14, no.2, pp.541 - 544-
dc.identifier.issn0960-894X-
dc.identifier.urihttp://hdl.handle.net/10203/80894-
dc.description.abstractNovel quinoxaline antibiotics having the methylenedithioether bridge as an analogue of echinomycin have been synthesized by insertion of methylene moiety between -S-S- bond. The compound la shows remarkable cytotoxicities against human tumor various cell lines, and is active VRE (vancomycin-resistant enterococci) within MIC range 0.5-8 mug/mL. According to the eukaryotic or prokaryotic data, la might be a first analogue to replace echinomycin. (C) 2003 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectDES-N-TETRAMETHYLTRIOSTIN-
dc.subjectTHIOL PROTECTING GROUP-
dc.subjectTRIOSTIN-A-
dc.subjectDERIVATIVES-
dc.subjectACID-
dc.subjectCYSTEINE-
dc.subjectCYSTINE-
dc.subjectBINDING-
dc.titleSynthesis and biological activity of new quinoxaline antibiotics of echinomycin analogues-
dc.typeArticle-
dc.identifier.wosid000188119500053-
dc.identifier.scopusid2-s2.0-0346729859-
dc.type.rimsART-
dc.citation.volume14-
dc.citation.issue2-
dc.citation.beginningpage541-
dc.citation.endingpage544-
dc.citation.publicationnameBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.identifier.doi10.1016/j.bmcl.2003.09.086-
dc.contributor.nonIdAuthorKim Y.B.-
dc.contributor.nonIdAuthorPark J.Y.-
dc.contributor.nonIdAuthorKim S.K.-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorechinomycin-
dc.subject.keywordAuthoranticancer-
dc.subject.keywordAuthoractive-VRE-
dc.subject.keywordAuthorapoptosis-
dc.subject.keywordPlusDES-N-TETRAMETHYLTRIOSTIN-
dc.subject.keywordPlusTHIOL PROTECTING GROUP-
dc.subject.keywordPlusTRIOSTIN-A-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusACID-
dc.subject.keywordPlusCYSTEINE-
dc.subject.keywordPlusCYSTINE-
dc.subject.keywordPlusBINDING-
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