DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, HY | ko |
dc.contributor.author | Ji, YM | ko |
dc.contributor.author | Yu, YK | ko |
dc.contributor.author | Yu, JY | ko |
dc.contributor.author | Lee, Younghoon | ko |
dc.contributor.author | Leet, SJ | ko |
dc.date.accessioned | 2013-03-03T22:58:01Z | - |
dc.date.available | 2013-03-03T22:58:01Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2003-12 | - |
dc.identifier.citation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.24, no.12, pp.1819 - 1826 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.uri | http://hdl.handle.net/10203/80821 | - |
dc.description.abstract | In connection with the studies for developing new enzymes that could be useful in organic synthesis, practical preparation of racemic and enantiopure forms of gamma-hydroxy-alpha-keto acids has been successfully achieved. For racemic form of gamma-hydroxy-alpha-keto acids, indium-mediated allylation of aldehydes with 2-(bromomethyl)acrylic acid has been employed as a key step. Oxidative cleavage of the thus formed 2-methylenebutyrolactones provided the desired alpha-ketobutyrolactones. Enzymatic resolution of the 7-hydroxy-alpha-methylene esters provided the desired gamma-hydroxy-alpha-methylene acids which were successfully converted to gamma-hydroxy-alpha-ketobutyrolactones in optically pure forms. | - |
dc.language | English | - |
dc.publisher | KOREAN CHEMICAL SOC | - |
dc.title | Synthesis of alpha-ketobutyrolactones and gamma-hydroxy-alpha-keto acids | - |
dc.type | Article | - |
dc.identifier.wosid | 000187747600021 | - |
dc.identifier.scopusid | 2-s2.0-0346374773 | - |
dc.type.rims | ART | - |
dc.citation.volume | 24 | - |
dc.citation.issue | 12 | - |
dc.citation.beginningpage | 1819 | - |
dc.citation.endingpage | 1826 | - |
dc.citation.publicationname | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.contributor.localauthor | Lee, Younghoon | - |
dc.contributor.nonIdAuthor | Kang, HY | - |
dc.contributor.nonIdAuthor | Ji, YM | - |
dc.contributor.nonIdAuthor | Yu, YK | - |
dc.contributor.nonIdAuthor | Yu, JY | - |
dc.contributor.nonIdAuthor | Leet, SJ | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | alpha-ketobutyrolactones | - |
dc.subject.keywordAuthor | gamma-hydroxy-alpha-keto acids | - |
dc.subject.keywordAuthor | indium | - |
dc.subject.keywordAuthor | enzymes | - |
dc.subject.keywordAuthor | enantiomeric resolution | - |
dc.subject.keywordPlus | INDIUM-PROMOTED PREPARATION | - |
dc.subject.keywordPlus | PSEUDOMONAS SP. DJ77 | - |
dc.subject.keywordPlus | CARBONYL-COMPOUNDS | - |
dc.subject.keywordPlus | STRAIN DJ77 | - |
dc.subject.keywordPlus | ALLYLATION REACTIONS | - |
dc.subject.keywordPlus | SEQUENCE-ANALYSIS | - |
dc.subject.keywordPlus | ALDOL REACTIONS | - |
dc.subject.keywordPlus | LACTONES | - |
dc.subject.keywordPlus | DEHYDROGENASE | - |
dc.subject.keywordPlus | ENANTIOMERS | - |
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