Isoflavones stimulate estrogen receptor-mediated core histone acetylation

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dc.contributor.authorHong, Taoko
dc.contributor.authorNakagawa, Takeyako
dc.contributor.authorPan, WeiJunko
dc.contributor.authorKim, Mi Youngko
dc.contributor.authorKraus, W. Leeko
dc.contributor.authorIkehara, Tsuyoshiko
dc.contributor.authorYasui, Kiyoshiko
dc.contributor.authorAihara, Hitoshiko
dc.contributor.authorTakebe, Minoruko
dc.contributor.authorMuramatsu, Masamiko
dc.contributor.authorIto, Takashiko
dc.date.accessioned2013-03-03T16:29:21Z-
dc.date.available2013-03-03T16:29:21Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2004-04-
dc.identifier.citationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.317, no.1, pp.259 - 264-
dc.identifier.issn0006-291X-
dc.identifier.urihttp://hdl.handle.net/10203/79465-
dc.description.abstractThe isoflavones genistein and daidzein and the daidzein metabolite equol have been reported to interact with estrogen receptors (ERs). Some studies indicate that they behave clinically like estrogen in some estrogen-deficiency diseases. However, the detailed molecular mechanism used by these compounds to create beneficial effects in patients with estrogen-related diseases has not been clarified. Using historic acetyltransferase (HAT) assay, we found that equol, genistein, and AglyMax had significant effects on ERalpha-mediated historic acetylation. Although 17beta-estradiol (E2)-dependent HAT activity of steroid receptor coactivators 2 (SRC2) and p300 mediated by ERbeta could be detected, it was weaker than that mediated by ERalpha. Equol, genistein, AglyMax, and daidzein all markedly stimulated ERbeta-mediated histone acetylation. On the other hand, anti-estrogenic compounds ICI 182,780 (ICI) and tamoxifen (TA) did not have an effect on HAT activity mediated by either ERalpha or ERbeta. Our data indicate that estrogenic ligands exert their effects by elevating histone acetylation and coactivator activity of ER, and suggest that the risk of estrogen-related diseases might be reduced by a sufficient amount of genistein or AglyMax supplements. (C) 2004 Elsevier Inc. All rights reserved.-
dc.languageEnglish-
dc.publisherAcademic Press Inc Elsevier Science-
dc.subjectLOW-DENSITY-LIPOPROTEIN-
dc.subjectTRANSCRIPTIONAL REGULATION-
dc.subjectPOSTMENOPAUSAL WOMEN-
dc.subjectBINDING PROTEIN-
dc.subjectPHYTOESTROGENS-
dc.subjectCOACTIVATORS-
dc.subjectSOY-
dc.subjectALPHA-
dc.subjectBETA-
dc.subjectP300-
dc.titleIsoflavones stimulate estrogen receptor-mediated core histone acetylation-
dc.typeArticle-
dc.identifier.wosid000220725700037-
dc.identifier.scopusid2-s2.0-12144290788-
dc.type.rimsART-
dc.citation.volume317-
dc.citation.issue1-
dc.citation.beginningpage259-
dc.citation.endingpage264-
dc.citation.publicationnameBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.identifier.doi10.1016/j.bbrc.2004.03.041-
dc.contributor.localauthorKim, Mi Young-
dc.contributor.nonIdAuthorHong, Tao-
dc.contributor.nonIdAuthorNakagawa, Takeya-
dc.contributor.nonIdAuthorPan, WeiJun-
dc.contributor.nonIdAuthorKraus, W. Lee-
dc.contributor.nonIdAuthorIkehara, Tsuyoshi-
dc.contributor.nonIdAuthorYasui, Kiyoshi-
dc.contributor.nonIdAuthorAihara, Hitoshi-
dc.contributor.nonIdAuthorTakebe, Minoru-
dc.contributor.nonIdAuthorMuramatsu, Masami-
dc.contributor.nonIdAuthorIto, Takashi-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorestrogen receptor-
dc.subject.keywordAuthorhistone acetylation-
dc.subject.keywordAuthorestradiol-
dc.subject.keywordAuthorgenistein-
dc.subject.keywordAuthordaidzein-
dc.subject.keywordAuthorequol-
dc.subject.keywordAuthorAglyMax-
dc.subject.keywordPlusLOW-DENSITY-LIPOPROTEIN-
dc.subject.keywordPlusTRANSCRIPTIONAL REGULATION-
dc.subject.keywordPlusPOSTMENOPAUSAL WOMEN-
dc.subject.keywordPlusBINDING PROTEIN-
dc.subject.keywordPlusPHYTOESTROGENS-
dc.subject.keywordPlusCOACTIVATORS-
dc.subject.keywordPlusSOY-
dc.subject.keywordPlusALPHA-
dc.subject.keywordPlusBETA-
dc.subject.keywordPlusP300-
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