DC Field | Value | Language |
---|---|---|
dc.contributor.author | K.Y.Cho | ko |
dc.contributor.author | H.E.Moon | ko |
dc.contributor.author | H.Moini | ko |
dc.contributor.author | L.Packer | ko |
dc.contributor.author | D.Y.Yoon | ko |
dc.contributor.author | Chung, An Sik | ko |
dc.date.accessioned | 2013-03-03T14:33:28Z | - |
dc.date.available | 2013-03-03T14:33:28Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2003-09 | - |
dc.identifier.citation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.278, no.37, pp.34823 - 34833 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | http://hdl.handle.net/10203/79094 | - |
dc.description.abstract | Obesity is associated with a number of pathological disorders such as non-insulin-dependent diabetes, hypertension, hyperlipidemia, and cardiovascular diseases. alpha-Lipoic acid (LA) has been demonstrated to activate the insulin signaling pathway and to exert insulin-like actions in adipose and muscle cells. Based on this similarity LA is expected to promote adipogenesis in pre-adipocytes. Here, however, we report that LA inhibited differentiation of 3T3-L1 pre-adipocytes induced by a hormonal mixture or troglitazone. Northern blot analysis of cells demonstrated that this inhibition was accompanied with attenuated expression of adipocyte-specific fatty acid-binding protein and lipoprotein lipase. Electrophoretic mobility shift assay and Western blot analysis of cells demonstrated that LA modulates transcriptional activity and/or expression of a set of anti- or pro-adipogenic transcription factors. LA treatment of 3T3-L1 pre-adipocytes also resulted in prolonged activation of major mitogen-activated protein kinase signaling pathways but showed little or no effect on the activity of the insulin receptor/Akt signaling pathway. These findings suggest that LA inhibits insulin or the hormonal mixture-induced differentiation of 3T3-L1 pre-adipocytes by modulating activity and/or expression of pro- or anti- adipogenic transcription factors mainly through activating the MAPK pathways. | - |
dc.language | English | - |
dc.publisher | Amer Soc Biochemistry Molecular Biology Inc | - |
dc.subject | TUMOR-NECROSIS-FACTOR | - |
dc.subject | LIPOPROTEIN-LIPASE GENE | - |
dc.subject | RECEPTOR-GAMMA | - |
dc.subject | SIGNALING PATHWAY | - |
dc.subject | 3T3-L1 ADIPOCYTES | - |
dc.subject | GLUCOSE-UPTAKE | - |
dc.subject | PPAR-GAMMA | - |
dc.subject | KAPPA-B | - |
dc.subject | EXPRESSION | - |
dc.subject | CELLS | - |
dc.title | Alpha-lipoic acid inhibits adipocyte differentiation by regulating pro-adipogenic transcription factors via mitogen-activated protein kinase pathways | - |
dc.type | Article | - |
dc.identifier.wosid | 000185164400013 | - |
dc.identifier.scopusid | 2-s2.0-0042818386 | - |
dc.type.rims | ART | - |
dc.citation.volume | 278 | - |
dc.citation.issue | 37 | - |
dc.citation.beginningpage | 34823 | - |
dc.citation.endingpage | 34833 | - |
dc.citation.publicationname | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.contributor.nonIdAuthor | K.Y.Cho | - |
dc.contributor.nonIdAuthor | H.E.Moon | - |
dc.contributor.nonIdAuthor | H.Moini | - |
dc.contributor.nonIdAuthor | L.Packer | - |
dc.contributor.nonIdAuthor | D.Y.Yoon | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | LIPOPROTEIN-LIPASE GENE | - |
dc.subject.keywordPlus | RECEPTOR-GAMMA | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | 3T3-L1 ADIPOCYTES | - |
dc.subject.keywordPlus | GLUCOSE-UPTAKE | - |
dc.subject.keywordPlus | PPAR-GAMMA | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CELLS | - |
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