DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ko, HM | ko |
dc.contributor.author | Seo, KH | ko |
dc.contributor.author | Han, SJ | ko |
dc.contributor.author | Ahn, KY | ko |
dc.contributor.author | Choi, IH | ko |
dc.contributor.author | Koh, Gou Young | ko |
dc.contributor.author | Lee, HK | ko |
dc.contributor.author | Ra, MS | ko |
dc.contributor.author | Im, SY | ko |
dc.date.accessioned | 2013-03-03T10:53:12Z | - |
dc.date.available | 2013-03-03T10:53:12Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2002-03 | - |
dc.identifier.citation | CANCER RESEARCH, v.62, no.6, pp.1809 - 1814 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.uri | http://hdl.handle.net/10203/78408 | - |
dc.description.abstract | This study investigated the mechanisms of platelet-activating factor (PAF)-induced angiogenesis in a mouse model of Matrigel implantation. PAF induced a dose- and time-dependent angiogenic response. Inhibitors of nuclear factor (NF) kappaB expression or action, including antisense oligonucleotides to the p65 subunit of NFkappaB (p65 antisense) and antioxidants such as alpha-tocopherol and N-acetyl-L-cysteine, significantly reduced PAF-induced angiogenesis. In human umbilical vein endothelial cells, PAF-induced mRNA expression and protein synthesis of various NFkappaB-dependent angiogenic factors, such as tumor necrosis factor-alpha, interleukin-la, basic fibroblast growth factor, and vascular endothelial growth factor (VEGF). The PAF-induced expression of the above mentioned factors was inhibited by p65 antisense or antioxidants. A significant inhibition of the angiogenic effect of PAF was achieved by anti-VEGF antibodies or soluble VEGF receptors such as KDR and flt-1 but not by antibodies against tumor necrosis factor-alpha, interleukin-1alpha, or basic fibroblast growth factor. These data indicate that PAF enhances angiogenesis through inducing NFkappaB activation, which in turn promotes the production of angiogenic factors such as VEGF. | - |
dc.language | English | - |
dc.publisher | AMER ASSOC CANCER RESEARCH | - |
dc.subject | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject | NECROSIS-FACTOR-ALPHA | - |
dc.subject | IN-VIVO ANGIOGENESIS | - |
dc.subject | TRANSCRIPTION FACTOR | - |
dc.subject | REDOX REGULATION | - |
dc.subject | BREAST-CANCER | - |
dc.subject | PAF-ACETHER | - |
dc.subject | FACTOR-C | - |
dc.subject | CELLS | - |
dc.subject | EXPRESSION | - |
dc.title | Nuclear factor kappa B dependency of platelet-activating factor-induced angiogenesis | - |
dc.type | Article | - |
dc.identifier.wosid | 000174560200036 | - |
dc.identifier.scopusid | 2-s2.0-0037085569 | - |
dc.type.rims | ART | - |
dc.citation.volume | 62 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 1809 | - |
dc.citation.endingpage | 1814 | - |
dc.citation.publicationname | CANCER RESEARCH | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.nonIdAuthor | Ko, HM | - |
dc.contributor.nonIdAuthor | Seo, KH | - |
dc.contributor.nonIdAuthor | Han, SJ | - |
dc.contributor.nonIdAuthor | Ahn, KY | - |
dc.contributor.nonIdAuthor | Choi, IH | - |
dc.contributor.nonIdAuthor | Lee, HK | - |
dc.contributor.nonIdAuthor | Ra, MS | - |
dc.contributor.nonIdAuthor | Im, SY | - |
dc.type.journalArticle | Article | - |
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