DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yun, SH | ko |
dc.contributor.author | Cheong, MY | ko |
dc.contributor.author | Mook-Jung, I | ko |
dc.contributor.author | Huh, K | ko |
dc.contributor.author | Lee, CJ | ko |
dc.contributor.author | Jung, MW | ko |
dc.date.accessioned | 2013-03-03T09:14:41Z | - |
dc.date.available | 2013-03-03T09:14:41Z | - |
dc.date.created | 2013-02-20 | - |
dc.date.created | 2013-02-20 | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | NEUROSCIENCE, v.97, no.4, pp.671 - 676 | - |
dc.identifier.issn | 0306-4522 | - |
dc.identifier.uri | http://hdl.handle.net/10203/78152 | - |
dc.description.abstract | Effects of cholinergic agents on synaptic transmission and plasticity were examined in entorhinal cortex and hippocampus. Bath application of carbachol (0.25-0.75 mu M) induced transient depression of field potential responses in all cases tested (24/24 in layer III of medial entorhinal cortex slices and 24/24 in CA1 of hippocampal slices; 11.0 +/- 1.9% and 7.8 +/- 2.5%, respectively) and long-lasting potentiation in some cases (4/24 in entorhinal cortex and 12/24 in hippocampus; 33.7 +/- 3.7% and 32.1 +/- 9.9%, respectively, in successful cases). Carbachol (0.5 mu M) induced transient depression, but not long-lasting potentiation, of N-methyl-D-aspartate receptor-mediated responses in entorhinal cortex. At 5 mu M, carbachol induced transient depression only (55.9 +/-14.7% in entorhinal cortex and 41.4 +/- 2.9% in hippocampus), which was blocked by atropine. Paired-pulse facilitation was not altered during carbachol-induced potentiation but enhanced during carbachol induced depression. These results suggest that the underlying mechanisms of carbachol induced depression and potentiation are decreased transmitter release and selective enhancement of non-N-methyl-D-aspartate receptor-mediated responses, respectively. Long-term potentiation could be induced in the presence of 10 mu M atropine by theta burst stimulation. The magnitude was significantly lower (15.2 +/- 5.2%, n=9) compared with control (37.2 +/-: 6.1%, n = 8) in entorhinal cortex, however. These results demonstrate similar, but not identical, cholinergic modulation of synaptic transmission and plasticity in entorhinal cortex and hippocampus. (C) 2000 IBRO. Published by Elsevier Science Ltd. | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | LONG-TERM POTENTIATION | - |
dc.subject | VOLTAGE-CLAMP ANALYSIS | - |
dc.subject | MUSCARINIC RECEPTORS | - |
dc.subject | GUINEA-PIG | - |
dc.subject | LAYER-II | - |
dc.subject | PYRAMIDAL CELLS | - |
dc.subject | CEREBRAL-CORTEX | - |
dc.subject | CA1 REGION | - |
dc.subject | NEURONS | - |
dc.subject | SLICES | - |
dc.title | Cholinergic modulation of synaptic transmission and plasticity ln entorhinal cortex and hippocampus of the rat | - |
dc.type | Article | - |
dc.identifier.wosid | 000087641700006 | - |
dc.identifier.scopusid | 2-s2.0-0034075227 | - |
dc.type.rims | ART | - |
dc.citation.volume | 97 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 671 | - |
dc.citation.endingpage | 676 | - |
dc.citation.publicationname | NEUROSCIENCE | - |
dc.identifier.doi | 10.1016/S0306-4522(00)00108-1 | - |
dc.contributor.localauthor | Jung, MW | - |
dc.contributor.nonIdAuthor | Yun, SH | - |
dc.contributor.nonIdAuthor | Cheong, MY | - |
dc.contributor.nonIdAuthor | Mook-Jung, I | - |
dc.contributor.nonIdAuthor | Huh, K | - |
dc.contributor.nonIdAuthor | Lee, CJ | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | acetylcholine | - |
dc.subject.keywordAuthor | long-term potentiation | - |
dc.subject.keywordAuthor | muscarinic receptor | - |
dc.subject.keywordAuthor | brain slice | - |
dc.subject.keywordAuthor | carbachol | - |
dc.subject.keywordAuthor | memory | - |
dc.subject.keywordPlus | LONG-TERM POTENTIATION | - |
dc.subject.keywordPlus | VOLTAGE-CLAMP ANALYSIS | - |
dc.subject.keywordPlus | MUSCARINIC RECEPTORS | - |
dc.subject.keywordPlus | GUINEA-PIG | - |
dc.subject.keywordPlus | LAYER-II | - |
dc.subject.keywordPlus | PYRAMIDAL CELLS | - |
dc.subject.keywordPlus | CEREBRAL-CORTEX | - |
dc.subject.keywordPlus | CA1 REGION | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | SLICES | - |
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