An improved synthesis of levofloxacin
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kang, SB | ko |
| dc.contributor.author | Park, S | ko |
| dc.contributor.author | Kim, Yong Hae | ko |
| dc.contributor.author | Kim, Y | ko |
| dc.date.accessioned | 2013-03-03T09:13:36Z | - |
| dc.date.available | 2013-03-03T09:13:36Z | - |
| dc.date.created | 2012-02-06 | - |
| dc.date.created | 2012-02-06 | - |
| dc.date.issued | 1997-01 | - |
| dc.identifier.citation | HETEROCYCLES, v.45, no.1, pp.137 - 145 | - |
| dc.identifier.issn | 0385-5414 | - |
| dc.identifier.uri | http://hdl.handle.net/10203/78147 | - |
| dc.description.abstract | The benzoxazinecarboxylic acid (8), a precursor of levofloxacin (1), was prepared from (S)-2-amino-1-propanol (2) in 4 steps in good overall yield. The synthesis is characterized by one pot construction of 8 from the useful benzoylacrylates (7) which are effectively prepared in three steps. The key intermediates (7) were obtained from 2-nitrobenzoyl derivative (6a) and 2-fluorobenzoyl derivative (6b) through acylation of the acrylates (5), respectively. | - |
| dc.language | English | - |
| dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
| dc.title | An improved synthesis of levofloxacin | - |
| dc.type | Article | - |
| dc.identifier.wosid | A1997WJ19100017 | - |
| dc.type.rims | ART | - |
| dc.citation.volume | 45 | - |
| dc.citation.issue | 1 | - |
| dc.citation.beginningpage | 137 | - |
| dc.citation.endingpage | 145 | - |
| dc.citation.publicationname | HETEROCYCLES | - |
| dc.contributor.nonIdAuthor | Kang, SB | - |
| dc.contributor.nonIdAuthor | Park, S | - |
| dc.contributor.nonIdAuthor | Kim, Y | - |
| dc.type.journalArticle | Article | - |
| dc.subject.keywordPlus | OPTICALLY-ACTIVE OFLOXACIN | - |
| dc.subject.keywordPlus | ANTIBACTERIAL ACTIVITIES | - |
| dc.subject.keywordPlus | DERIVATIVES | - |
| dc.subject.keywordPlus | AGENT | - |
| dc.subject.keywordPlus | ACIDS | - |
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