DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, HJ | ko |
dc.contributor.author | Song, MR | ko |
dc.contributor.author | Lee, SK | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.contributor.author | Choi, YH | ko |
dc.contributor.author | Kim, SJ | ko |
dc.contributor.author | Lee, JW | ko |
dc.contributor.author | Lee, MO | ko |
dc.date.accessioned | 2013-03-03T07:28:35Z | - |
dc.date.available | 2013-03-03T07:28:35Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2000-05 | - |
dc.identifier.citation | EXPERIMENTAL CELL RESEARCH, v.256, no.2, pp.545 - 554 | - |
dc.identifier.issn | 0014-4827 | - |
dc.identifier.uri | http://hdl.handle.net/10203/77774 | - |
dc.description.abstract | Nur77 (NGFI-B) is an orphan. nuclear receptor that has been implicated in activation-induced T-cell apoptosis. Retinoids, potent immune modulators, were shown to inhibit the activation-induced apoptosis of immature thymocytes and T-cell hybridomas. To illustrate the mechanism of the inhibition, we examined the effects of retinoic acid (RA) on the expression and transactivation functions of Nur77 in the human peripheral blood mononuclear cells and the human T-cell leukemia, Jurkat. All-trans-RA remarkably repressed the DNA binding and transcriptional induction of Nur77. Among the two potential transacting factors that activate Nur77 gene promoter, i.e., AP-1 and related serum response factor (RSRF), all-trans-RA repressed DNA binding and reporter gene activity of AP-1 but not that of RSRF, suggesting that the inhibition may be mediated through AP-1. We also demonstrated a posttranscriptional regulation of Nur77 function by retinoid receptors by showing that transactivation activity of Nur77 was significantly inhibited by cotransfection of RAR alpha or RXR alpha. Nur77 bound RAR alpha or RXR alpha in both yeast and mammalian two-hybrid tests, suggesting that direct protein-protein interaction between these receptors may mediate the inhibition. Taken all together, we demonstrated that RA repressed Nur77 function through multiple mechanisms that may provide the basis for RA inhibition on the apoptosis of activated T-lymphocytes. (C) 2000 Academic Press. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC | - |
dc.subject | ACTIVATION-INDUCED APOPTOSIS | - |
dc.subject | ORPHAN STEROID-RECEPTOR | - |
dc.subject | T-CELL APOPTOSIS | - |
dc.subject | SERUM GROWTH-FACTORS | - |
dc.subject | NGFI-B | - |
dc.subject | FAS LIGAND | - |
dc.subject | GENE NUR77 | - |
dc.subject | NUCLEAR RECEPTORS | - |
dc.subject | X-RECEPTOR | - |
dc.subject | PC12 CELLS | - |
dc.title | Retinoic acid and its receptors repress the expression and transactivation functions of Nur77: A possible mechanism for the inhibition of apoptosis by retinoic acid | - |
dc.type | Article | - |
dc.identifier.wosid | 000086888500020 | - |
dc.identifier.scopusid | 2-s2.0-0034192212 | - |
dc.type.rims | ART | - |
dc.citation.volume | 256 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 545 | - |
dc.citation.endingpage | 554 | - |
dc.citation.publicationname | EXPERIMENTAL CELL RESEARCH | - |
dc.identifier.doi | 10.1006/excr.2000.4832 | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Kang, HJ | - |
dc.contributor.nonIdAuthor | Song, MR | - |
dc.contributor.nonIdAuthor | Lee, SK | - |
dc.contributor.nonIdAuthor | Choi, YH | - |
dc.contributor.nonIdAuthor | Kim, SJ | - |
dc.contributor.nonIdAuthor | Lee, JW | - |
dc.contributor.nonIdAuthor | Lee, MO | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | retinoic acid | - |
dc.subject.keywordAuthor | Nur77 | - |
dc.subject.keywordAuthor | T-lymphocytes | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | RAR | - |
dc.subject.keywordAuthor | RXR | - |
dc.subject.keywordPlus | ACTIVATION-INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | ORPHAN STEROID-RECEPTOR | - |
dc.subject.keywordPlus | T-CELL APOPTOSIS | - |
dc.subject.keywordPlus | SERUM GROWTH-FACTORS | - |
dc.subject.keywordPlus | NGFI-B | - |
dc.subject.keywordPlus | FAS LIGAND | - |
dc.subject.keywordPlus | GENE NUR77 | - |
dc.subject.keywordPlus | NUCLEAR RECEPTORS | - |
dc.subject.keywordPlus | X-RECEPTOR | - |
dc.subject.keywordPlus | PC12 CELLS | - |
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