DC Field | Value | Language |
---|---|---|
dc.contributor.author | Doyle, DA | ko |
dc.contributor.author | Lee, A | ko |
dc.contributor.author | Lewis, J | ko |
dc.contributor.author | Kim, Eunjoon | ko |
dc.contributor.author | Sheng, M | ko |
dc.contributor.author | MacKinnon, R | ko |
dc.date.accessioned | 2013-03-03T06:16:32Z | - |
dc.date.available | 2013-03-03T06:16:32Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1996-06 | - |
dc.identifier.citation | CELL, v.85, no.7, pp.1067 - 1076 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.uri | http://hdl.handle.net/10203/77590 | - |
dc.description.abstract | Modular PDZ domains, found in many cell junction-associated proteins, mediate the clustering of membrane ion channels by binding to their C-terminus. The X-ray crystallographic structures of the third PDZ domain from the synaptic protein PSD-95 in complex with and in the absence of its peptide ligand have been determined at 1.8 Angstrom and 2.3 Angstrom resolution, respectively. The structures reveal that a four-residue C-terminal stretch (X-Thr/Ser-X-Val-COO-) engages the PDZ domain through antiparallel main chain interactions with a beta sheet of the domain. Recognition of the terminal carboxylate group of the peptide is conferred by a cradle of main chain amides provided by a Gly-Leu-Gly-Phe loop as well as by an arginine side chain. Specific side chain interactions and a prominent hydrophobic pocket explain the selective recognition of the C-terminal consensus sequence. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.subject | TUMOR-SUPPRESSOR PROTEIN | - |
dc.subject | SEPTATE JUNCTIONS | - |
dc.subject | HOMOLOG | - |
dc.title | Crystal structures of a complexed and peptide-free membrane protein-binding domain: Molecular basis of peptide recognition by PDZ | - |
dc.type | Article | - |
dc.identifier.wosid | A1996UV48400013 | - |
dc.identifier.scopusid | 2-s2.0-0030604722 | - |
dc.type.rims | ART | - |
dc.citation.volume | 85 | - |
dc.citation.issue | 7 | - |
dc.citation.beginningpage | 1067 | - |
dc.citation.endingpage | 1076 | - |
dc.citation.publicationname | CELL | - |
dc.identifier.doi | 10.1016/S0092-8674(00)81307-0 | - |
dc.contributor.localauthor | Kim, Eunjoon | - |
dc.contributor.nonIdAuthor | Doyle, DA | - |
dc.contributor.nonIdAuthor | Lee, A | - |
dc.contributor.nonIdAuthor | Lewis, J | - |
dc.contributor.nonIdAuthor | Sheng, M | - |
dc.contributor.nonIdAuthor | MacKinnon, R | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR PROTEIN | - |
dc.subject.keywordPlus | SEPTATE JUNCTIONS | - |
dc.subject.keywordPlus | HOMOLOG | - |
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