We need to solve various mobility problems in 1- dimensional, 2-dimensional, and 3-dimensimonal micro- or picocell environments for efficiently planning future personal communications services. However, mobility problems have been thus far studied in 1- and 2-dimensional cell structures. In this paper, we extend the previous mobility modeling from 1- or 2-dimensional space to 3-dimensional indoor building environments by considering proper boundary conditions on each floor and analytically model the mobility in multi-story buildings to estimate the number of handoffs and then verify this mathematical model by computer simulations. These results can be utilized in the network plannings of future personal communications services.