DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, J.-C. | ko |
dc.contributor.author | Kim, M.-S. | ko |
dc.contributor.author | Kim, Jong-Duk | ko |
dc.date.accessioned | 2013-03-02T21:11:02Z | - |
dc.date.available | 2013-03-02T21:11:02Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | KOREAN JOURNAL OF CHEMICAL ENGINEERING, v.16, no.1, pp.28 - 33 | - |
dc.identifier.issn | 0256-1115 | - |
dc.identifier.uri | http://hdl.handle.net/10203/75531 | - |
dc.description.abstract | Novel temperature-sensitive liposomes containing hydrophobically modified poly(N-isopropylacrylamide) (HPNIPAM) and their release behaviors were investigated using calcein as a fluorescence probe. Above the lower critical solution temperature (LCST) of the polymer (e.g., 40 degrees C), the degree of calcein release in 280 sec from reverse-phase evaporation vesicles (REVs) of egg phosphatidylcholine (egg PC) was 43 %, while egg PC MLVs was 16 %. Such a large difference of release may be attributed to the lamellarity of liposomes. The incorporation of dioleoylphosphatidylethanolamine (DOPE) into the PC bilayer enhanced the release by 10-13 % at 40 degrees C, probably due to the increased instability of mixture bilayers. Meanwhile, a temperature-sensitive device of DOPE liposomes was prepared by using HPNIPAM as a stabilizer. The optimal ratio of HPNIPAM to lipid to stabilize the bilayer was 0.1. Above the LCST (e.g., 40 degrees C), the release percentage was about 80 % of the entrapped calcein. DOPE liposomes were the most temperature-sensitive among liposomes tested. This is probably because DOPE liposomes disintegrate into a non-liposomal phase, such as hexagonal (H-Pi), by a thermal contraction of HPNIPAM. | - |
dc.language | English | - |
dc.publisher | KOREAN INST CHEM ENGINEERS | - |
dc.subject | PHOSPHATIDYLETHANOLAMINE | - |
dc.subject | CARRIERS | - |
dc.subject | DELIVERY | - |
dc.subject | DRUGS | - |
dc.title | Temperature-sensitive releases from liposomes containing hydrophobically modified poly(N-isopropylacrylamide) | - |
dc.type | Article | - |
dc.identifier.wosid | 000078558500004 | - |
dc.identifier.scopusid | 2-s2.0-0033434910 | - |
dc.type.rims | ART | - |
dc.citation.volume | 16 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 28 | - |
dc.citation.endingpage | 33 | - |
dc.citation.publicationname | KOREAN JOURNAL OF CHEMICAL ENGINEERING | - |
dc.identifier.doi | 10.1007/BF02699001 | - |
dc.contributor.localauthor | Kim, Jong-Duk | - |
dc.contributor.nonIdAuthor | Kim, J.-C. | - |
dc.contributor.nonIdAuthor | Kim, M.-S. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | liposomes | - |
dc.subject.keywordAuthor | poly(N-isopropylacrylamide) | - |
dc.subject.keywordAuthor | temperature-sensitivity | - |
dc.subject.keywordAuthor | dioleoylphosphatidylethanolamine | - |
dc.subject.keywordAuthor | reverse-phase evaporation vesicles | - |
dc.subject.keywordPlus | PHOSPHATIDYLETHANOLAMINE | - |
dc.subject.keywordPlus | CARRIERS | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | DRUGS | - |
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