A novel antimicrobial peptide from Bufo bufo gargarizans

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dc.contributor.authorPark, CBko
dc.contributor.authorKim, MSko
dc.contributor.authorKim, Sun-Changko
dc.date.accessioned2013-03-02T18:40:45Z-
dc.date.available2013-03-02T18:40:45Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued1996-01-
dc.identifier.citationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.218, no.1, pp.408 - 413-
dc.identifier.issn0006-291X-
dc.identifier.urihttp://hdl.handle.net/10203/74951-
dc.description.abstractA potent and structurally novel antimicrobial peptide was isolated and characterized from the stomach tissue of Bufo bufo gargarizans, an Asian toad. The 39-amino acid peptide, named buforin I, was purified to homogeneity by heparin-affinity column and reverse-phase HPLC. The amino acid sequence of buforin I was identical in 37 of 39 amino-terminal residues of Xenopus histone H2A. The buforin I showed strong antimicrobial activities in vitro against a broad-spectrum of microorganisms and was found to be more potent than magainin 2. In addition, a 21-amino acid peptide, named buforin II, which was derived from buforin I, showed more potent antimicrobial activities than buforin I. (C) 1996 Academic Press, Inc.-
dc.languageEnglish-
dc.publisherELSEVIER SCIENCE-
dc.subjectANTIBIOTIC PEPTIDES-
dc.subjectLIPID BILAYERS-
dc.subjectMAGAININ-2-
dc.subjectCHANNELS-
dc.subjectSKIN-
dc.titleA novel antimicrobial peptide from Bufo bufo gargarizans-
dc.typeArticle-
dc.identifier.wosidA1996TP75400071-
dc.identifier.scopusid2-s2.0-0030068934-
dc.type.rimsART-
dc.citation.volume218-
dc.citation.issue1-
dc.citation.beginningpage408-
dc.citation.endingpage413-
dc.citation.publicationnameBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.identifier.doi10.1006/bbrc.1996.0071-
dc.contributor.localauthorKim, Sun-Chang-
dc.contributor.nonIdAuthorPark, CB-
dc.contributor.nonIdAuthorKim, MS-
dc.type.journalArticleArticle-
dc.subject.keywordPlusANTIBIOTIC PEPTIDES-
dc.subject.keywordPlusLIPID BILAYERS-
dc.subject.keywordPlusMAGAININ-2-
dc.subject.keywordPlusCHANNELS-
dc.subject.keywordPlusSKIN-
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