DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, HS | ko |
dc.contributor.author | Park, CB | ko |
dc.contributor.author | Kim, MS | ko |
dc.contributor.author | Kim, Sun-Chang | ko |
dc.date.accessioned | 2013-03-02T18:24:30Z | - |
dc.date.available | 2013-03-02T18:24:30Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1996-12 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.229, no.2, pp.381 - 387 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10203/74891 | - |
dc.description.abstract | A cDNA containing coding information for buforin I, the toad stomach antimicrobial peptide, was identified by PCR. The cloned cDNA encoded a protein of 129 amino acids whose 39-amino-acid N-terminus was identical to buforin I. Nucleotide sequence analysis of the cloned cDNA revealed that it had over 90% amino acid homology with histone H2A, the replication-dependent protein. Both Northern and Southern blot analysis of the toad genome suggested that histone H2A and buforin I were encoded by the same gene. A specific protease responsible for the generation of buforin I from histone H2A was found to be present in the crude extracts of the toad stomach. These results suggest that there exists a specific regulation mechanism which converts the toad histone H2A to the antimicrobial peptide buforin I. (C) 1996 Academic Press. Inc. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS | - |
dc.subject | XENOPUS-LAEVIS | - |
dc.subject | MESSENGER-RNA | - |
dc.subject | SEQUENCE | - |
dc.subject | SKIN | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | DEGRADATION | - |
dc.subject | GENES | - |
dc.subject | FROG | - |
dc.subject | SITE | - |
dc.subject | END | - |
dc.title | cDNA cloning and characterization of buforin I, an antimicrobial peptide: A cleavage product of histone H2A | - |
dc.type | Article | - |
dc.identifier.wosid | A1996VZ79900004 | - |
dc.identifier.scopusid | 2-s2.0-0030582631 | - |
dc.type.rims | ART | - |
dc.citation.volume | 229 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 381 | - |
dc.citation.endingpage | 387 | - |
dc.citation.publicationname | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.identifier.doi | 10.1006/bbrc.1996.1814 | - |
dc.contributor.localauthor | Kim, Sun-Chang | - |
dc.contributor.nonIdAuthor | Kim, HS | - |
dc.contributor.nonIdAuthor | Park, CB | - |
dc.contributor.nonIdAuthor | Kim, MS | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | XENOPUS-LAEVIS | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | SEQUENCE | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordPlus | FROG | - |
dc.subject.keywordPlus | SITE | - |
dc.subject.keywordPlus | END | - |
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