DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hsueh, YP (Hsueh, YP) | ko |
dc.contributor.author | Kim, Eunjoon | ko |
dc.contributor.author | Sheng, M (Sheng, M) | ko |
dc.date.accessioned | 2013-03-02T14:26:25Z | - |
dc.date.available | 2013-03-02T14:26:25Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1997-05 | - |
dc.identifier.citation | NEURON, v.18, no.5, pp.803 - 814 | - |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.uri | http://hdl.handle.net/10203/73971 | - |
dc.description.abstract | The PSD-95/SAP90 family of PDZ-containing proteins is directly involved in the clustering of specific ion channels at synapses. We report that channel clustering depends on a conserved N-terminal domain of PSD-95 that mediates multimerization and disulfide linkage of PSD-95 protomers. This N-terminal multimerization domain confers channel clustering activity on a single PDZ domain. Thus, channel clustering depends on aggregation of PDZ domains achieved by head-to-head multimerization of PSD-95, rather than by concatenation of PDZ domains in PSD-95 monomers. This mechanism predicts that PSD-95 can organize heterogeneous membrane protein clusters via differential binding specificities of its three PDZ domains. PSD-95 and its relative chapsyn-110 exist as disulfide-linked complexes in rat brain, consistent with head-to-head multimerization of these proteins in vivo. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.subject | TUMOR-SUPPRESSOR PROTEIN | - |
dc.subject | GUANYLATE KINASES | - |
dc.subject | K+ CHANNELS | - |
dc.subject | SYNAPSES | - |
dc.subject | HOMOLOG | - |
dc.subject | SAP90 | - |
dc.title | Disulfide-linked head-to-head multimerization in the mechanism of ion channel clustering by PSD-95 | - |
dc.type | Article | - |
dc.identifier.wosid | A1997XB72200013 | - |
dc.identifier.scopusid | 2-s2.0-0030921919 | - |
dc.type.rims | ART | - |
dc.citation.volume | 18 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 803 | - |
dc.citation.endingpage | 814 | - |
dc.citation.publicationname | NEURON | - |
dc.identifier.doi | 10.1016/S0896-6273(00)80319-0 | - |
dc.contributor.localauthor | Kim, Eunjoon | - |
dc.contributor.nonIdAuthor | Hsueh, YP (Hsueh, YP) | - |
dc.contributor.nonIdAuthor | Sheng, M (Sheng, M) | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR PROTEIN | - |
dc.subject.keywordPlus | GUANYLATE KINASES | - |
dc.subject.keywordPlus | K+ CHANNELS | - |
dc.subject.keywordPlus | SYNAPSES | - |
dc.subject.keywordPlus | HOMOLOG | - |
dc.subject.keywordPlus | SAP90 | - |
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