DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, HG | ko |
dc.contributor.author | Koh, Gou Young | ko |
dc.date.accessioned | 2013-03-02T14:00:57Z | - |
dc.date.available | 2013-03-02T14:00:57Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2000-03 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.269, no.2, pp.401 - 405 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10203/73867 | - |
dc.description.abstract | Vascular endothelial cells release proteinases that degrade the extracellular matrix, thus enabling cell migration during angiogenesis and vasculogenesis. Endothelial cells secrete mainly the preform of matrix metalloproteinase-2 (proMMP-2). In this report, we examined several growth factors, cytokines, and other molecules for activation of MMP-2 by human umbilical vein endothelial cells. Of these factors, we found that lipopolysaccharide (LPS) is the strongest activator of MMP-2. LPS induced MMP-2 activation in a time- and dose-dependent manner. While pretreatment with zinc chelators or nuclear factor kappa B (NF-kappa B) inhibitors suppressed LPS-induced MMP-2 activation, pretreatment with phosphatidylinositol S'-kinase inhibitors had no effect. These results indicate that, in endothelial cells, LPS can directly enhance angiogenesis by inducing MMP-2 activation mediated through an NF-kappa B pathway, (C) 2000 Academic Press. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC | - |
dc.subject | BACTERIAL LIPOPOLYSACCHARIDE | - |
dc.subject | EXTRACELLULAR-MATRIX | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | MECHANISMS | - |
dc.subject | ENDOTOXIN | - |
dc.title | Lipopolysaccharide activates matrix metalloproteinase-2 in endothelial cells through an NF-kappa B-dependent pathway | - |
dc.type | Article | - |
dc.identifier.wosid | 000086023600020 | - |
dc.identifier.scopusid | 2-s2.0-0343603584 | - |
dc.type.rims | ART | - |
dc.citation.volume | 269 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 401 | - |
dc.citation.endingpage | 405 | - |
dc.citation.publicationname | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.nonIdAuthor | Kim, HG | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | BACTERIAL LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | EXTRACELLULAR-MATRIX | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | ENDOTOXIN | - |
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