DC Field | Value | Language |
---|---|---|
dc.contributor.author | Naisbitt, S | ko |
dc.contributor.author | Kim, Eunjoon | ko |
dc.contributor.author | Tu, JC | ko |
dc.contributor.author | Xiao, B | ko |
dc.contributor.author | Sala, C | ko |
dc.contributor.author | Valtschanoff, J | ko |
dc.contributor.author | Weinberg, RJ | ko |
dc.contributor.author | Worley, PF | ko |
dc.contributor.author | Sheng, M | ko |
dc.date.accessioned | 2013-02-28T06:43:21Z | - |
dc.date.available | 2013-02-28T06:43:21Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1999-07 | - |
dc.identifier.citation | NEURON, v.23, no.3, pp.569 - 582 | - |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.uri | http://hdl.handle.net/10203/73311 | - |
dc.description.abstract | NMDA receptors are linked to intracellular cytoskeletal and signaling molecules via the PSD-95 protein complex. We report a novel family of postsynaptic density (PSD) proteins, termed Shank, that binds via its PDZ domain to the C terminus of PSD-95-associated protein GKAP. A ternary complex of Shank/GKAP/PSD-95 assembles in heterologous cells and can be coimmunoprecipitated from rat brain. Synaptic localization of Shank in neurons is inhibited by a GKAP splice variant that lacks the Shank-binding C terminus. In addition to its PDZ domain, Shank contains a proline-rich region that binds to cortactin and a SAM domain that mediates multimerization. Shank may function as a scaffold protein in the PSD, potentially cross-linking NMDA receptor/PSD-95 complexes and coupling them to regulators of the actin cytoskeleton. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.subject | METABOTROPIC GLUTAMATE RECEPTORS | - |
dc.subject | TUMOR-SUPPRESSOR PROTEIN | - |
dc.subject | RAT-BRAIN | - |
dc.subject | EXCITATORY SYNAPSES | - |
dc.subject | HIPPOCAMPAL-NEURONS | - |
dc.subject | WW DOMAINS | - |
dc.subject | INTERACTS | - |
dc.subject | ACTIN | - |
dc.subject | PDZ | - |
dc.subject | RECOGNITION | - |
dc.title | Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin | - |
dc.type | Article | - |
dc.identifier.wosid | 000081701000020 | - |
dc.identifier.scopusid | 2-s2.0-0033165926 | - |
dc.type.rims | ART | - |
dc.citation.volume | 23 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 569 | - |
dc.citation.endingpage | 582 | - |
dc.citation.publicationname | NEURON | - |
dc.identifier.doi | 10.1016/S0896-6273(00)80809-0 | - |
dc.contributor.localauthor | Kim, Eunjoon | - |
dc.contributor.nonIdAuthor | Naisbitt, S | - |
dc.contributor.nonIdAuthor | Tu, JC | - |
dc.contributor.nonIdAuthor | Xiao, B | - |
dc.contributor.nonIdAuthor | Sala, C | - |
dc.contributor.nonIdAuthor | Valtschanoff, J | - |
dc.contributor.nonIdAuthor | Weinberg, RJ | - |
dc.contributor.nonIdAuthor | Worley, PF | - |
dc.contributor.nonIdAuthor | Sheng, M | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | METABOTROPIC GLUTAMATE RECEPTORS | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR PROTEIN | - |
dc.subject.keywordPlus | RAT-BRAIN | - |
dc.subject.keywordPlus | EXCITATORY SYNAPSES | - |
dc.subject.keywordPlus | HIPPOCAMPAL-NEURONS | - |
dc.subject.keywordPlus | WW DOMAINS | - |
dc.subject.keywordPlus | INTERACTS | - |
dc.subject.keywordPlus | ACTIN | - |
dc.subject.keywordPlus | PDZ | - |
dc.subject.keywordPlus | RECOGNITION | - |
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