DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Eunjoon | ko |
dc.contributor.author | Cho, Kyungok | ko |
dc.contributor.author | Rothschild, A | ko |
dc.contributor.author | Sheng, M | ko |
dc.date.accessioned | 2013-02-28T06:11:58Z | - |
dc.date.available | 2013-02-28T06:11:58Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1996-07 | - |
dc.identifier.citation | NEURON, v.17, no.1, pp.103 - 113 | - |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.uri | http://hdl.handle.net/10203/73171 | - |
dc.description.abstract | Chapsyn-110, a novel membrane-associated putative guanylate kinase (MAGUK) that binds directly to N-methyl-D-aspartate (NMDA) receptor and Shaker K+ channel subunits, is 70%-80% identical to, and shares an identical domain organization with, PSD-95/SAP90 and SAP97. In rat brain, chapsyn-110 protein shows a somatodendritic expression pattern that overlaps partly with PSD-95 but that contrasts with the axonal distribution of SAP97. Chapsyn-110 associates tightly with the postsynaptic density in brain, and mediates the clustering of both NMDA receptors and K+ channels in heterologous cells. Indeed, chapsyn-110 and PSD-95 can heteromultimerize with each other and are recruited into the same NMDA receptor and K, channel clusters. Thus, chapsyn-110 and PSD-95 may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signalling proteins. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.subject | TUMOR-SUPPRESSOR GENE | - |
dc.subject | MOLECULAR CHARACTERIZATION | - |
dc.subject | SUBCELLULAR-LOCALIZATION | - |
dc.subject | CHANNEL PROTEINS | - |
dc.subject | K+ CHANNELS | - |
dc.subject | RAT-BRAIN | - |
dc.subject | SUBUNIT | - |
dc.subject | HOMOLOG | - |
dc.subject | NEURONS | - |
dc.subject | CLONING | - |
dc.title | Heteromultimerization and NMDA receptor-clustering activity of chapsyn-110, a member of the PSD-95 family of proteins | - |
dc.type | Article | - |
dc.identifier.wosid | A1996UY98100011 | - |
dc.identifier.scopusid | 2-s2.0-0030200438 | - |
dc.type.rims | ART | - |
dc.citation.volume | 17 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 103 | - |
dc.citation.endingpage | 113 | - |
dc.citation.publicationname | NEURON | - |
dc.identifier.doi | 10.1016/S0896-6273(00)80284-6 | - |
dc.contributor.localauthor | Kim, Eunjoon | - |
dc.contributor.localauthor | Cho, Kyungok | - |
dc.contributor.nonIdAuthor | Rothschild, A | - |
dc.contributor.nonIdAuthor | Sheng, M | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR GENE | - |
dc.subject.keywordPlus | MOLECULAR CHARACTERIZATION | - |
dc.subject.keywordPlus | SUBCELLULAR-LOCALIZATION | - |
dc.subject.keywordPlus | CHANNEL PROTEINS | - |
dc.subject.keywordPlus | K+ CHANNELS | - |
dc.subject.keywordPlus | RAT-BRAIN | - |
dc.subject.keywordPlus | SUBUNIT | - |
dc.subject.keywordPlus | HOMOLOG | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | CLONING | - |
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