DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim Jaeseob | ko |
dc.date.accessioned | 2013-02-28T03:43:05Z | - |
dc.date.available | 2013-02-28T03:43:05Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1997-07 | - |
dc.identifier.citation | NATURE, v.388, no.6639, pp.304 - 308 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | http://hdl.handle.net/10203/72610 | - |
dc.description.abstract | The TGF-beta (transforming growth factor-beta)-related signalling proteins, including Decapentaplegic (Dpp) in Drosophila and bone morphogenic proteins and activin in vertebrates, affect the growth and patterning of a great variety of structures. However, the mechanisms by which these ligands regulate gene expression are not understood. Activation of complexes of type I with type II receptors results in the phosphorylation and nuclear localization of members of the SMAD protein family(1-9), which are thought to act as co-activators of transcription, perhaps in conjunction with sequence-specific cofactors(10). Here we show that the aminoterminal domain of the Drosophila Mothers against dpp protein (Mad), a mediator of Dpp signalling(11-14), possesses a sequence-specific DNA-binding activity that becomes apparent when carboxy-terminal residues are removed. Mad binds to and is required for the activation of an enhancer within the vestigial wing-patterning gene in cells across the entire developing wing blade. Mad also binds to Dpp-response elements in other genes. These results suggest that Dpp signalling regulates gene expression by activating Mad binding to target gene enhancers. | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.subject | HEDGEHOG | - |
dc.subject | EXPRESSION | - |
dc.subject | MELANOGASTER | - |
dc.subject | ELEMENTS | - |
dc.subject | PATTERN | - |
dc.subject | PROTEIN | - |
dc.subject | GENE | - |
dc.subject | DPP | - |
dc.title | Drosophila MAD binds to DNA and directly mediates activation of vestigial by Decapentaplegic. | - |
dc.type | Article | - |
dc.identifier.wosid | A1997XL12100058 | - |
dc.identifier.scopusid | 2-s2.0-0030872367 | - |
dc.type.rims | ART | - |
dc.citation.volume | 388 | - |
dc.citation.issue | 6639 | - |
dc.citation.beginningpage | 304 | - |
dc.citation.endingpage | 308 | - |
dc.citation.publicationname | NATURE | - |
dc.contributor.localauthor | Kim Jaeseob | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | HEDGEHOG | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MELANOGASTER | - |
dc.subject.keywordPlus | ELEMENTS | - |
dc.subject.keywordPlus | PATTERN | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | DPP | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.