Drosophila MAD binds to DNA and directly mediates activation of vestigial by Decapentaplegic.

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dc.contributor.authorKim Jaeseobko
dc.date.accessioned2013-02-28T03:43:05Z-
dc.date.available2013-02-28T03:43:05Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued1997-07-
dc.identifier.citationNATURE, v.388, no.6639, pp.304 - 308-
dc.identifier.issn0028-0836-
dc.identifier.urihttp://hdl.handle.net/10203/72610-
dc.description.abstractThe TGF-beta (transforming growth factor-beta)-related signalling proteins, including Decapentaplegic (Dpp) in Drosophila and bone morphogenic proteins and activin in vertebrates, affect the growth and patterning of a great variety of structures. However, the mechanisms by which these ligands regulate gene expression are not understood. Activation of complexes of type I with type II receptors results in the phosphorylation and nuclear localization of members of the SMAD protein family(1-9), which are thought to act as co-activators of transcription, perhaps in conjunction with sequence-specific cofactors(10). Here we show that the aminoterminal domain of the Drosophila Mothers against dpp protein (Mad), a mediator of Dpp signalling(11-14), possesses a sequence-specific DNA-binding activity that becomes apparent when carboxy-terminal residues are removed. Mad binds to and is required for the activation of an enhancer within the vestigial wing-patterning gene in cells across the entire developing wing blade. Mad also binds to Dpp-response elements in other genes. These results suggest that Dpp signalling regulates gene expression by activating Mad binding to target gene enhancers.-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.subjectHEDGEHOG-
dc.subjectEXPRESSION-
dc.subjectMELANOGASTER-
dc.subjectELEMENTS-
dc.subjectPATTERN-
dc.subjectPROTEIN-
dc.subjectGENE-
dc.subjectDPP-
dc.titleDrosophila MAD binds to DNA and directly mediates activation of vestigial by Decapentaplegic.-
dc.typeArticle-
dc.identifier.wosidA1997XL12100058-
dc.identifier.scopusid2-s2.0-0030872367-
dc.type.rimsART-
dc.citation.volume388-
dc.citation.issue6639-
dc.citation.beginningpage304-
dc.citation.endingpage308-
dc.citation.publicationnameNATURE-
dc.contributor.localauthorKim Jaeseob-
dc.type.journalArticleArticle-
dc.subject.keywordPlusHEDGEHOG-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusMELANOGASTER-
dc.subject.keywordPlusELEMENTS-
dc.subject.keywordPlusPATTERN-
dc.subject.keywordPlusPROTEIN-
dc.subject.keywordPlusGENE-
dc.subject.keywordPlusDPP-
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