Diastereoselective Addition of Organolithiums to New Chiral Hydrazones. Enantioselective Synthesis of (R)- Coniine

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The reactions of organolithiums with the new chiral hydrazones derived from (S)-indoline-2-carboxylic acid afforded chiral hydrazines with Ugh diastereoselectivities (up to 99% de) and the present method was utilized for the preparation of high optically pure (R)-coniine (94% se). Copyright (C) 1996 Elsevier Science Ltd
Publisher
Pergamon-Elsevier Science Ltd
Issue Date
1996-07
Language
English
Article Type
Article
Keywords

ALDEHYDE-SAMP HYDRAZONES; ALPHA-AMINO ACIDS; ASYMMETRIC-SYNTHESIS; DIASTEREOFACIAL SELECTIVITY; GRIGNARD-REAGENTS; PIPERIDINES; ALKALOIDS; IMINES; ORGANOMETALLICS; (-)-CONIINE

Citation

TETRAHEDRON LETTERS, v.37, no.31, pp.5543 - 5546

ISSN
0040-4039
URI
http://hdl.handle.net/10203/72401
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