DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, N | ko |
dc.contributor.author | Jaeseob, Kim | ko |
dc.contributor.author | Park, D | ko |
dc.contributor.author | Rosen, C | ko |
dc.contributor.author | Dorsett, D | ko |
dc.contributor.author | Yim, J | ko |
dc.date.accessioned | 2013-02-28T02:24:04Z | - |
dc.date.available | 2013-02-28T02:24:04Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1996-04 | - |
dc.identifier.citation | GENETICS, v.142, no.4, pp.1157 - 1168 | - |
dc.identifier.issn | 0016-6731 | - |
dc.identifier.uri | http://hdl.handle.net/10203/72270 | - |
dc.description.abstract | Viable mutant alleles of purple (pr), such as pr(bw), exhibit mutant eye colors. This reflects low 6-pyruvoyl tetrahydropterin (PTP) synthase activity required for pigment synthesis. PTP synthase is also required for synthesis of the enzyme cofactor biopterin; presumably this is why some pr alleles are lethal. The pr(bw) eye color phenotype is suppressed by suppressor of sable [su(s)] mutations. The pr gene was cloned to explore the mechanism of this suppression. pr produces two PTP synthase mRNAs: one constitutively from a distal promoter and one in late pupae and young adult heads from a proximal promoter. The latter presumably supports eye pigment synthesis. The pr(bw) allele has a 412 retrotransposon in an intron spliced from both mRNAs. However, the head-specific mRNA is reduced > 10-fold in pr(bw) and is restored by a su(s) mutation, while the constitutive transcript is barely affected. The Su(s) protein probably alters processing of RNA containing 412. Because the intron containing 412 is the first in the head-specific mRNA and the second in the constitutive mRNA, binding of splicing machinery to nascent transcripts before the 412 insertion is transcribed may preclude the effects of Su(s) protein. | - |
dc.language | English | - |
dc.publisher | GENETICS | - |
dc.subject | MELANOGASTER VERMILION GENE | - |
dc.subject | 6-PYRUVOYL-TETRAHYDROPTERIN SYNTHASE | - |
dc.subject | CDNA CLONING | - |
dc.subject | BITHORAX COMPLEX | - |
dc.subject | LOCUS | - |
dc.subject | RNA | - |
dc.subject | PURIFICATION | - |
dc.subject | BIOSYNTHESIS | - |
dc.subject | TRANSCRIPTS | - |
dc.subject | AMPLIFICATION | - |
dc.title | Structure and expression of wild-type and suppressible alleles of the Drosophila purple gene | - |
dc.type | Article | - |
dc.identifier.wosid | A1996UD84400009 | - |
dc.type.rims | ART | - |
dc.citation.volume | 142 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 1157 | - |
dc.citation.endingpage | 1168 | - |
dc.citation.publicationname | GENETICS | - |
dc.contributor.localauthor | Jaeseob, Kim | - |
dc.contributor.nonIdAuthor | Kim, N | - |
dc.contributor.nonIdAuthor | Park, D | - |
dc.contributor.nonIdAuthor | Rosen, C | - |
dc.contributor.nonIdAuthor | Dorsett, D | - |
dc.contributor.nonIdAuthor | Yim, J | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | MELANOGASTER VERMILION GENE | - |
dc.subject.keywordPlus | 6-PYRUVOYL-TETRAHYDROPTERIN SYNTHASE | - |
dc.subject.keywordPlus | CDNA CLONING | - |
dc.subject.keywordPlus | BITHORAX COMPLEX | - |
dc.subject.keywordPlus | LOCUS | - |
dc.subject.keywordPlus | RNA | - |
dc.subject.keywordPlus | PURIFICATION | - |
dc.subject.keywordPlus | BIOSYNTHESIS | - |
dc.subject.keywordPlus | TRANSCRIPTS | - |
dc.subject.keywordPlus | AMPLIFICATION | - |
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