DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nerenberg, JB | ko |
dc.contributor.author | Erb, JM | ko |
dc.contributor.author | Thompson, WJ | ko |
dc.contributor.author | Lee, Hee Yoon | ko |
dc.contributor.author | Guare, JP | ko |
dc.contributor.author | Munson, PM | ko |
dc.contributor.author | Bergman, JM | ko |
dc.contributor.author | Huff, JR | ko |
dc.contributor.author | Broten, TP | ko |
dc.contributor.author | Chang, RSL | ko |
dc.contributor.author | Chen, TB | ko |
dc.contributor.author | O'Malley, S | ko |
dc.contributor.author | Schorn, TW | ko |
dc.contributor.author | Scott, AL | ko |
dc.date.accessioned | 2013-02-27T23:46:18Z | - |
dc.date.available | 2013-02-27T23:46:18Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1998-09 | - |
dc.identifier.citation | BIOORGANIC MEDICINAL CHEMISTRY LETTERS, v.8, no.18, pp.2467 - 2472 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | http://hdl.handle.net/10203/71556 | - |
dc.description.abstract | Benign prostatic hyperplasia can be managed pharmacologically with alpha-1 adrenergic receptor antagonists. Agents that demonstrate selectivity for the alpha-1a receptor subtype may offer advantages in clinical applications with respect to hypotensive side effects. The N-alkylated saccharins reported here represent a new class of subtype selective alpha-1a adrenergic receptor antagonists which demonstrate potent effects on prostate function in vivo and are devoid of blood pressure side effects. (C) 1998 Elsevier Science Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | BENIGN PROSTATIC HYPERPLASIA | - |
dc.subject | ALPHA(1C) | - |
dc.subject | EFFICACY | - |
dc.subject | SAFETY | - |
dc.title | Design and synthesis of N-alkylated saccharins as selective alpha-1A adrenergic receptor antagonists | - |
dc.type | Article | - |
dc.identifier.wosid | 000076271200012 | - |
dc.identifier.scopusid | 2-s2.0-16744364284 | - |
dc.type.rims | ART | - |
dc.citation.volume | 8 | - |
dc.citation.issue | 18 | - |
dc.citation.beginningpage | 2467 | - |
dc.citation.endingpage | 2472 | - |
dc.citation.publicationname | BIOORGANIC MEDICINAL CHEMISTRY LETTERS | - |
dc.identifier.doi | 10.1016/S0960-894X(98)00446-6 | - |
dc.contributor.localauthor | Lee, Hee Yoon | - |
dc.contributor.nonIdAuthor | Nerenberg, JB | - |
dc.contributor.nonIdAuthor | Erb, JM | - |
dc.contributor.nonIdAuthor | Thompson, WJ | - |
dc.contributor.nonIdAuthor | Guare, JP | - |
dc.contributor.nonIdAuthor | Munson, PM | - |
dc.contributor.nonIdAuthor | Bergman, JM | - |
dc.contributor.nonIdAuthor | Huff, JR | - |
dc.contributor.nonIdAuthor | Broten, TP | - |
dc.contributor.nonIdAuthor | Chang, RSL | - |
dc.contributor.nonIdAuthor | Chen, TB | - |
dc.contributor.nonIdAuthor | O'Malley, S | - |
dc.contributor.nonIdAuthor | Schorn, TW | - |
dc.contributor.nonIdAuthor | Scott, AL | - |
dc.type.journalArticle | Article; Proceedings Paper | - |
dc.subject.keywordPlus | BENIGN PROSTATIC HYPERPLASIA | - |
dc.subject.keywordPlus | ALPHA(1C) | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | SAFETY | - |
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