DC Field | Value | Language |
---|---|---|
dc.contributor.author | Young Yang | ko |
dc.contributor.author | Hyun Mi You | ko |
dc.contributor.author | Inpyo Choi | ko |
dc.contributor.author | Kwang Ho Pyun | ko |
dc.contributor.author | Byun, Si Myung | ko |
dc.contributor.author | Hyunjung Ha | ko |
dc.date.accessioned | 2013-02-27T18:11:20Z | - |
dc.date.available | 2013-02-27T18:11:20Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1996 | - |
dc.identifier.citation | JOURNAL OF INVESTIGATIVE DERMATOLOGY, v.107, no.3, pp.367 - 372 | - |
dc.identifier.issn | 0022-202X | - |
dc.identifier.uri | http://hdl.handle.net/10203/70020 | - |
dc.description.abstract | We studied the effect of IL-4 on the proliferation of cultured normal human keratinocytes. Keratinocyte proliferation was stimulated by IL-4 and inhibited by anti-IL-4 antibody in a concentration-dependent manner, Anti-IL-6 antibody did not inhibit normal human keratinocyte proliferation, suggesting that the IL-4 could directly induce proliferation of these cells, IL-4 significantly induced cell cycle G(0)/G(1) to S phase progression, The keratinocyte proliferation by IL-4 was mediated through one of the growth control genes, c-myc protooncogene. The expression of c-myc mRNA was significantly increased after IL-4 treatment of the keratinocytes, suggesting that c-myr: plays a key role in the control of proliferation, The signal transduction pathways induced by IL-4 in the keratinocytes were studied with inhibitors of signal transduction. Genistein, a tyrosine kinase inhibitor, suppressed the level of the induced c-myc mRNA expression, but H7, a serine/threonine kinase inhibitor, and okadaic acid, a protein phosphatase 1 and 2A inhibitor, did not block the induced c-myr: gene expression, Taken together, these results suggest that IL-4 stimulates the proliferation of keratinocytes in vitro by promoting a transition from G(0)/G(1) to S phase of the cell cycle, Induction of c-myc after IL-4 treatment could indicate an important role for c-myc in the proliferation of keratinocytes. Our observations also suggest that tyrosine kinases may be involved in IL-4-induced proliferation. | - |
dc.language | English | - |
dc.publisher | BLACKWELL SCIENCE INC | - |
dc.subject | INTERFERON-GAMMA | - |
dc.subject | PROTEIN | - |
dc.subject | CELL | - |
dc.subject | FOS | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | FIBROBLASTS | - |
dc.subject | SIGNAL | - |
dc.subject | PHASE | - |
dc.subject | SKIN | - |
dc.title | Interleukin 4-induced proliferation in normal human keratinocytes is associated with c-myc gene expression and inhibited by genistein | - |
dc.type | Article | - |
dc.identifier.wosid | A1996VD79000015 | - |
dc.identifier.scopusid | 2-s2.0-0029793184 | - |
dc.type.rims | ART | - |
dc.citation.volume | 107 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 367 | - |
dc.citation.endingpage | 372 | - |
dc.citation.publicationname | JOURNAL OF INVESTIGATIVE DERMATOLOGY | - |
dc.contributor.nonIdAuthor | Young Yang | - |
dc.contributor.nonIdAuthor | Hyun Mi You | - |
dc.contributor.nonIdAuthor | Inpyo Choi | - |
dc.contributor.nonIdAuthor | Kwang Ho Pyun | - |
dc.contributor.nonIdAuthor | Hyunjung Ha | - |
dc.type.journalArticle | Article | - |
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