New anthracycline metabolites produced by the aklavinone 11-hydroxylase gene in Streptomyces galilaeus ATCC 31133

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Transformation of Streptomyces galilaeus ATCC 31133 with the aklavinone 11-hydroxylase gene (dnr F) resulted in the production of many red pigments. The new metabolites were purified and their structures were determined as 11-hydroxylated aclacinomycin A, B and T by spectral analysis. This result indicated that the dnrF was stably expressed in the strain S. galilaeus ATCC 31133 to give rise to hybrid aclacinomycins. In addition, a new aclacinomycin analog named 11-hydroxyaclacinomycin X was isolated from the same culture. Its structure was elucidated as 2'''amino-11-hydroxyaclacinomycin Y. It showed strong cytotoxicity against several human tumor cell lines, especially leukemia and melanoma cell lines.
Publisher
JAPAN ANTIBIOT RES ASSN
Issue Date
1996
Language
English
Article Type
Article
Keywords

BLOCKED MUTANT; ANTIBIOTICS

Citation

JOURNAL OF ANTIBIOTICS, v.49, no.4, pp.355 - 360

ISSN
0021-8820
URI
http://hdl.handle.net/10203/6837
Appears in Collection
MSE-Journal Papers(저널논문)
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