DC Field | Value | Language |
---|---|---|
dc.contributor.author | Koh, Gou Young | ko |
dc.contributor.author | NUSSENZVEIG, DR | ko |
dc.contributor.author | OKOLICANY, J | ko |
dc.contributor.author | PRICE, DA | ko |
dc.contributor.author | MAACK, T | ko |
dc.date.accessioned | 2013-02-27T07:23:04Z | - |
dc.date.available | 2013-02-27T07:23:04Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1992-06 | - |
dc.identifier.citation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.267, no.17, pp.11987 - 11994 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | http://hdl.handle.net/10203/67229 | - |
dc.description.abstract | The dynamics of the guanylate cyclase receptor of atrial natriuretic factor (GC(A)-ANF receptor) were investigated in cultured glomerular mesangial and renomedullary interstitial cells from the rat. In these cells, the GC(A)-ANF receptor did not mediate internalization and lysosomal hydrolysis of I-125-ANF1-28 and did not undergo ligand-induced endocytosis. Glomerular mesangial cells were able, however, to mediate internalization and lysosomal hydrolysis of I-125-ANF1-28 via clearance ANF (C-ANF) receptors and to promote rapid receptor-mediated internalization and lysosomal hydrolysis of I-125-(Sar1) angiotensin II. Radioligand specifically bound to surface GC(A)-ANF receptors was rapidly dissociated at 37-degrees-C (k(off) > 0.8 min-1), with a Q10(30-37-degrees-C) > 6. The dissociation was markedly slower at subphysiological temperatures (Q10(4-30-degrees-C), 2-3) or in the presence of 0.5 mM amiloride. The results demonstrate that the GC(A)-ANF receptor, contrary to C-ANF receptors and most other polypeptide hormone receptors, is a membrane resident protein that does not mediate internalization and lysosomal hydrolysis of ligand. The termination of the interaction of ANF with GC(A)-ANF receptors results from a physiological process that leads to rapid dissociation of receptor-ligand complexes. The unique dynamics of GC(A)-ANF receptor-ligand complexes are likely to contribute importantly to stimulus-response homeostasis of ANF. | - |
dc.language | English | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.subject | PEPTIDE CLEARANCE RECEPTOR | - |
dc.subject | ADRENAL ZONA GLOMERULOSA | - |
dc.subject | CYCLIC-GMP ACCUMULATION | - |
dc.subject | VASCULAR SMOOTH-MUSCLE | - |
dc.subject | RAT RENAL GLOMERULI | - |
dc.subject | INSULIN-RECEPTORS | - |
dc.subject | FUNCTIONAL EXPRESSION | - |
dc.subject | CYTOPLASMIC DOMAIN | - |
dc.subject | C RECEPTORS | - |
dc.subject | BINDING | - |
dc.title | DYNAMICS OF ATRIAL NATRIURETIC FACTOR-GUANYLATE CYCLASE RECEPTORS AND RECEPTOR-LIGAND COMPLEXES IN CULTURED GLOMERULAR MESANGIAL AND RENOMEDULLARY INTERSTITIAL-CELLS | - |
dc.type | Article | - |
dc.identifier.wosid | A1992HY94700053 | - |
dc.identifier.scopusid | 2-s2.0-0026769374 | - |
dc.type.rims | ART | - |
dc.citation.volume | 267 | - |
dc.citation.issue | 17 | - |
dc.citation.beginningpage | 11987 | - |
dc.citation.endingpage | 11994 | - |
dc.citation.publicationname | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.nonIdAuthor | NUSSENZVEIG, DR | - |
dc.contributor.nonIdAuthor | OKOLICANY, J | - |
dc.contributor.nonIdAuthor | PRICE, DA | - |
dc.contributor.nonIdAuthor | MAACK, T | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | PEPTIDE CLEARANCE RECEPTOR | - |
dc.subject.keywordPlus | ADRENAL ZONA GLOMERULOSA | - |
dc.subject.keywordPlus | CYCLIC-GMP ACCUMULATION | - |
dc.subject.keywordPlus | VASCULAR SMOOTH-MUSCLE | - |
dc.subject.keywordPlus | RAT RENAL GLOMERULI | - |
dc.subject.keywordPlus | INSULIN-RECEPTORS | - |
dc.subject.keywordPlus | FUNCTIONAL EXPRESSION | - |
dc.subject.keywordPlus | CYTOPLASMIC DOMAIN | - |
dc.subject.keywordPlus | C RECEPTORS | - |
dc.subject.keywordPlus | BINDING | - |
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