DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung SM | ko |
dc.contributor.author | Ahn DS | ko |
dc.contributor.author | Seok HS | ko |
dc.contributor.author | Jeong, Yong | ko |
dc.contributor.author | Kang BS | ko |
dc.date.accessioned | 2013-02-27T05:56:27Z | - |
dc.date.available | 2013-02-27T05:56:27Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1992-04 | - |
dc.identifier.citation | YONSEI MEDICAL JOURNAL, v.33, no.1, pp.14 - 23 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | http://hdl.handle.net/10203/66847 | - |
dc.description.abstract | Isolated rabbit aortic ring with intact endothelial cell preparations precontracted with NE (10(-7) M) were relaxed by vanadate in a dose dependent manner (from 0.2 to 2 mM). Application of vanadate and ACh during the tonic phase of high K+(100 mM)-induced contraction showed a slight relaxation in contrast to that in NE-induced contraction, but sodium nitroprusside (10 microM) more effectively relaxed the aortic ring preparations in high K+ contraction than that of vanadate. Vanadate-induced relaxation in NE-contracted aortic rings was reversed by application of BaCl2 (50 microM) or glibenclamide (10 microM). Furthermore, Vanadate hyperpolarized membrane potential of smooth muscle cells in endothelium-intact aortic strips and this effect was abolished by application of glibenclamide. The above results suggest that vanadate release EDHF (Endothelium-Derived Hyperpolarizing Factor), in addition to EDRF (Endothelium-Derived Relaxing Factor) from endothelial cell. This EDHF hyperpolarize the smooth muscle cell membrane potential via opening of the ATP-sensitive K+ channel and close a voltage dependent Ca++ channel. So it is suggested that the vanadate-induced relaxation of rabbit thoracic aortic rings may be due to the combined effects of EDRF and EDHF. | - |
dc.language | English | - |
dc.publisher | Yonsei Univ College Medicine | - |
dc.title | Effects of vanadate on vascular contractility and membrane potential in the rabbit aorta. | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.citation.volume | 33 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 14 | - |
dc.citation.endingpage | 23 | - |
dc.citation.publicationname | YONSEI MEDICAL JOURNAL | - |
dc.contributor.localauthor | Jeong, Yong | - |
dc.contributor.nonIdAuthor | Chung SM | - |
dc.contributor.nonIdAuthor | Ahn DS | - |
dc.contributor.nonIdAuthor | Seok HS | - |
dc.contributor.nonIdAuthor | Kang BS | - |
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