DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김종득 | ko |
dc.contributor.author | 김진철 | ko |
dc.contributor.author | 이은옥 | ko |
dc.date.accessioned | 2013-02-25T23:26:33Z | - |
dc.date.available | 2013-02-25T23:26:33Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1993-01 | - |
dc.identifier.citation | JOURNAL OF PHARMACEUTICAL INVESTIGATION, v.23, no.2, pp.111 - 118 | - |
dc.identifier.issn | 2093-5552 | - |
dc.identifier.uri | http://hdl.handle.net/10203/66000 | - |
dc.description.abstract | The hemolytic characteristics of amphotericin B-containing liposomes have been investigated in vitro. From the hemolysis of human erythrocytes against free and liposomal amphotericin B, the marked reduction in the toxicity of amphotericin B was observed by incorporating the drug in egg PC liposomes. For 45 min, free amphotericin B at $9.6\;{\mu}g/ml$ could completely lyse 2 wt% human erythrocytes. However, liposomal amphotericin B had essentially no lytic effect even in the range over $9.6\;{\mu}g/ml$. In the 66 hr-hemolysis experiment, liposomal amphotericin B showed the slowly hemolysing chracteristics during the experimental period regardless of the concentration of amphotericin B but rapid hemolysis only for 12 hr was observed in the case of free amphotericin B and the degree of hemolysis for 12 hr was maintained after that time. Also the hemolysing ability of liposomal amphotericin B at $4\;{\mu}g/ml$ was lower than that of free amphotericin B at the same concentration for 66 hr. On the other hand, the dependence of hemolysis on amphotericin B contents in egg PC liposomes was significant between 1.64 mole% amphotericin B-containing liposomes and 15.79 or 27.27 mole% amphotericin B-containing liposomes. But no marked difference in hemolysis was observed between 15.79 and 27.27 mole% amphotericin B-containing liposomes. Especially, cholesterol as an excipient in amphotericin B-containing liposomes significantly reduced the hemolysis of human erythrocyte. The degree of hemolysis in 5 mole% amphotericin B-containing liposomes was reduced to approximately 50% of value in the cholesterol-free liposomes by adding 50% cholesterol. | - |
dc.language | Korean | - |
dc.publisher | 한국약제학회 | - |
dc.title | Amphotericin B가 함유된 Egg PC 리포솜의 용혈 특성 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.citation.volume | 23 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 111 | - |
dc.citation.endingpage | 118 | - |
dc.citation.publicationname | JOURNAL OF PHARMACEUTICAL INVESTIGATION | - |
dc.contributor.localauthor | 김종득 | - |
dc.contributor.nonIdAuthor | 김진철 | - |
dc.contributor.nonIdAuthor | 이은옥 | - |
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