DC Field | Value | Language |
---|---|---|
dc.contributor.author | SEUL, KH | ko |
dc.contributor.author | CHO, KW | ko |
dc.contributor.author | KIM, SH | ko |
dc.contributor.author | HWANG, YH | ko |
dc.contributor.author | PARK, CU | ko |
dc.contributor.author | Koh, Gou Young | ko |
dc.date.accessioned | 2013-02-25T20:08:16Z | - |
dc.date.available | 2013-02-25T20:08:16Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1993 | - |
dc.identifier.citation | LIFE SCIENCES, v.52, pp.1351 - 1359 | - |
dc.identifier.issn | 0024-3205 | - |
dc.identifier.uri | http://hdl.handle.net/10203/64903 | - |
dc.description.abstract | To define the long-term effects of pentobarbital sodium on the plasma and atrial atrial natriuretic peptide (ANP) system, experiments were performed in female Sprague-Dawley rats. The plasma levels of immunoreactive (ir) ANP showed chronic as well as acute response to pentobarbital sodium administration. A single dose (30 mg/kg, i.p.) of pentobarbital sodium resulted in a suppression in the plasma levels of irANP up to 1 week of administration. The suppressive effect on plasma irANP concentrations was dose-dependent. Right but not left atrial contents of irANP increased by an administration of pentobarbital sodium up to 4 weeks. ANP mRNA contents of the atria exposed to pentobarbital sodium began to increase after 2 days, reached to the peak after 2 weeks, and began to return to control values after 6 weeks. Surgical stress accentuated these patterns of plasma and atrial ANP responses to pentobarbital sodium treatment. The present data, therefore, suggest that even a single anesthetic dose of pentobarbital could elicit long-lasting profound changes in ANP system, i.e., changes in gene expression, synthesis and the secretion of ANP. | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | NATRIURETIC-FACTOR | - |
dc.subject | MESSENGER-RNA | - |
dc.subject | PRESSURE | - |
dc.subject | PEPTIDE | - |
dc.subject | PLASMA | - |
dc.subject | SECRETION | - |
dc.title | SINGLE INJECTION OF PENTOBARBITAL INDUCES LONG-LASTING EFFECTS ON ANP SYNTHESIS AND GENE-EXPRESSION IN THE RAT ATRIA | - |
dc.type | Article | - |
dc.identifier.wosid | A1993KR48100003 | - |
dc.identifier.scopusid | 2-s2.0-0027509735 | - |
dc.type.rims | ART | - |
dc.citation.volume | 52 | - |
dc.citation.beginningpage | 1351 | - |
dc.citation.endingpage | 1359 | - |
dc.citation.publicationname | LIFE SCIENCES | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.nonIdAuthor | SEUL, KH | - |
dc.contributor.nonIdAuthor | CHO, KW | - |
dc.contributor.nonIdAuthor | KIM, SH | - |
dc.contributor.nonIdAuthor | HWANG, YH | - |
dc.contributor.nonIdAuthor | PARK, CU | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | NATRIURETIC-FACTOR | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | PRESSURE | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordPlus | SECRETION | - |
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