DC Field | Value | Language |
---|---|---|
dc.contributor.author | Stamm, Stefan | ko |
dc.contributor.author | Casper, Diana | ko |
dc.contributor.author | Leesmiller, James P. | ko |
dc.contributor.author | Helfman, David M | ko |
dc.date.accessioned | 2013-02-25T19:46:01Z | - |
dc.date.available | 2013-02-25T19:46:01Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1993-11 | - |
dc.identifier.citation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.90, no.21, pp.9857 - 9861 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10203/64804 | - |
dc.description.abstract | In this study we report on the developmental and regional expression of two brain-specific isoforms of tropomyosin, TMBr-1 and TMBr-3, that are generated from the rat alpha-tropomyosin gene via the use of alternative promoters and alternative RNA splicing. Western blot analysis using an exon-specific peptide polyclonal antibody revealed that the two isoforms are differentially expressed in development with TMBr-3 appearing in the embryonic brain at 16 days of gestation, followed by the expression of TMBr-1 at 20 days after birth. TMBr-3 was detected in all brain regions examined, whereas TMBr-1 was detected predominantly in brain areas that derive from the prosencephalon. Immunocytochemical studies on mixed primary cultures made from rat embryonic midbrain indicate that expression of the brain-specific epitope is restricted to neurons. The developmental pattern and neuronal localization of these forms of tropomyosin suggest that these isoforms have a specialized role in the development and plasticity of the nervous system. | - |
dc.language | English | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.subject | MESSENGER-RNAS | - |
dc.subject | PROTEIN | - |
dc.subject | GENE | - |
dc.subject | ACTIN | - |
dc.subject | POLYPEPTIDE | - |
dc.subject | BINDING | - |
dc.subject | NEURONS | - |
dc.subject | MYOSIN | - |
dc.title | BRAIN-SPECIFIC TROPOMYOSINS TMBR-1 AND TMBR-3 HAVE DISTINCT PATTERNS OF EXPRESSION DURING DEVELOPMENT AND IN ADULT BRAIN | - |
dc.type | Article | - |
dc.identifier.wosid | A1993MF29600024 | - |
dc.identifier.scopusid | 2-s2.0-0027375844 | - |
dc.type.rims | ART | - |
dc.citation.volume | 90 | - |
dc.citation.issue | 21 | - |
dc.citation.beginningpage | 9857 | - |
dc.citation.endingpage | 9861 | - |
dc.citation.publicationname | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.identifier.doi | 10.1073/pnas.90.21.9857 | - |
dc.contributor.localauthor | Helfman, David M | - |
dc.contributor.nonIdAuthor | Stamm, Stefan | - |
dc.contributor.nonIdAuthor | Casper, Diana | - |
dc.contributor.nonIdAuthor | Leesmiller, James P. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | MESSENGER-RNAS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | ACTIN | - |
dc.subject.keywordPlus | POLYPEPTIDE | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | MYOSIN | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.