IMMOBILIZATION CAN IMPROVE THE STABILITY OF HYBRIDOMA ANTIBODY PRODUCTIVITY IN SERUM-FREE MEDIA
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Lee, Gyun Min | ko |
| dc.contributor.author | Palsson, BO | ko |
| dc.date.accessioned | 2013-02-25T19:42:34Z | - |
| dc.date.available | 2013-02-25T19:42:34Z | - |
| dc.date.created | 2012-02-06 | - |
| dc.date.created | 2012-02-06 | - |
| dc.date.issued | 1990-12 | - |
| dc.identifier.citation | BIOTECHNOLOGY AND BIOENGINEERING, v.36, no.10, pp.1049 - 1055 | - |
| dc.identifier.issn | 0006-3592 | - |
| dc.identifier.uri | http://hdl.handle.net/10203/64785 | - |
| dc.description.abstract | Hybridoma cells (S3H5/γ2bA2) were cultivated in spinner flasks with 1% serum media and serum-free media. Monoclonal antibody productivity was maintained in 1% serum media. However, cells in serum-free media showed a decrease in antibody productivity, and it completely disappeared in IMDM-based low protein medium. This loss of antibody productivity was not observed when the cells were immobilized in alginate beads. In fact, immobilization enhanced the specific MAb productivity. | - |
| dc.language | English | - |
| dc.publisher | Wiley-VCH Verlag | - |
| dc.title | IMMOBILIZATION CAN IMPROVE THE STABILITY OF HYBRIDOMA ANTIBODY PRODUCTIVITY IN SERUM-FREE MEDIA | - |
| dc.type | Article | - |
| dc.identifier.wosid | A1990EJ24800009 | - |
| dc.identifier.scopusid | 2-s2.0-0025701405 | - |
| dc.type.rims | ART | - |
| dc.citation.volume | 36 | - |
| dc.citation.issue | 10 | - |
| dc.citation.beginningpage | 1049 | - |
| dc.citation.endingpage | 1055 | - |
| dc.citation.publicationname | BIOTECHNOLOGY AND BIOENGINEERING | - |
| dc.identifier.doi | 10.1002/bit.260361010 | - |
| dc.contributor.localauthor | Lee, Gyun Min | - |
| dc.contributor.nonIdAuthor | Palsson, BO | - |
| dc.description.isOpenAccess | N | - |
| dc.type.journalArticle | Article | - |
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