STEREOCONTROLLED CATALYTIC ASYMMETRIC REDUCTION OF KETONES WITH OXAZABOROLIDINES DERIVED FROM NEW CHIRAL AMINO-ALCOHOLS
The highly stereocontrolled enantioselective reduction of ketones in the presence of catalytic amounts of new chiral (S)-beta-amino alcohols 1 and 2 with borane in THF at -78-degrees-C proceeds in high chemical and optical yields; secondary alcohols with the R-configuration are obtained in the presence of 1b, but secondary alcohols with the S-configuration are obtained in the presence of 2a.
- Publisher
- AMER CHEMICAL SOC
- Issue Date
- 1993-08
- Language
- English
- Article Type
- Letter
- Keywords
PROCHIRAL AROMATIC KETONES; ENANTIOSELECTIVE REDUCTION; MODIFIED BOROHYDRIDES; OXIME ETHERS; BORANE; AMINOALCOHOLS; MECHANISM; EFFICIENT; REAGENTS
- Citation
JOURNAL OF ORGANIC CHEMISTRY, v.58, no.17, pp.4511 - 4512
- ISSN
- 0022-3263
- Appears in Collection
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