DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Kyungok | ko |
dc.contributor.author | HUNT, Carol A. | ko |
dc.contributor.author | KENNEDY, Mary B. | ko |
dc.date.accessioned | 2013-02-24T12:49:49Z | - |
dc.date.available | 2013-02-24T12:49:49Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1992-11 | - |
dc.identifier.citation | NEURON, v.9, no.5, pp.929 - 942 | - |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.uri | http://hdl.handle.net/10203/57266 | - |
dc.description.abstract | In CNS synapses, the synaptic junctional complex with associated postsynaptic density is presumed to contain proteins responsible for adhesion between pre- and postsynaptic membranes and for postsynaptic signal transduction. We have found that a prominent, brain-specific protein (PSD-95) enriched in the postsynaptic density fraction from rat brain is highly similar to the Drosophila lethal(1)discs-large-1 (dlg) tumor suppressor protein. The dlg protein is associated with septate junctions in developing flies and contains a guanylate kinase domain that is required for normal control of cell division. The sequence similarity between dlg and PSD-95 suggests that molecular mechanisms critical for growth control in developing organisms may also regulate synapse formation, stabilization, or function in the adult brain. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | The rat-brain postsynaptic density fraction contains a homolog of the drosophila disk-large tumor supressor protein | - |
dc.type | Article | - |
dc.identifier.wosid | A1992JY55200012 | - |
dc.identifier.scopusid | 2-s2.0-0026492629 | - |
dc.type.rims | ART | - |
dc.citation.volume | 9 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 929 | - |
dc.citation.endingpage | 942 | - |
dc.citation.publicationname | NEURON | - |
dc.identifier.doi | 10.1016/0896-6273(92)90245-9 | - |
dc.contributor.localauthor | Cho, Kyungok | - |
dc.contributor.nonIdAuthor | HUNT, Carol A. | - |
dc.contributor.nonIdAuthor | KENNEDY, Mary B. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | LONG-TERM POTENTIATION | - |
dc.subject.keywordPlus | CENTRAL NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | AMINO-ACID SEQUENCE | - |
dc.subject.keywordPlus | SIGNAL TRANSDUCTION | - |
dc.subject.keywordPlus | GUANYLATE KINASE | - |
dc.subject.keywordPlus | BINDING PROTEIN | - |
dc.subject.keywordPlus | CALMODULIN | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | JUNCTIONS | - |
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