DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Ho | ko |
dc.contributor.author | Lee, Dong Jun | ko |
dc.contributor.author | Oh, Sang Phil | ko |
dc.contributor.author | Park, Hee Dong | ko |
dc.contributor.author | Park, Hee Dong | ko |
dc.contributor.author | Nam, Hyun Hee | ko |
dc.contributor.author | Kim, Jin Man | ko |
dc.contributor.author | Lim, Dae-Sik | ko |
dc.date.accessioned | 2008-06-18T08:52:23Z | - |
dc.date.available | 2008-06-18T08:52:23Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2006-07 | - |
dc.identifier.citation | MOLECULAR AND CELLULAR BIOLOGY, v.26, pp.5373 - 5381 | - |
dc.identifier.issn | 0270-7306 | - |
dc.identifier.uri | http://hdl.handle.net/10203/5166 | - |
dc.description.abstract | For successful mitotic entry and spindle assembly, mitosis-promoting factors are activated at the G(2)/M transition stage, followed by stimulation of the anaphase-promoting complex (APC), an E3 ubiquitin ligase, to direct the ordered destruction of several critical mitotic regulators. Given that inhibition of APC activity is important for preventing premature or improper ubiquitination and destruction of substrates, several modulators and their regulation mechanisms have been studied. Emi1, an early mitotic inhibitor, is one of these regulatory factors. Here we show, by analyzing Emi1-deficient embryos, that Emi1 is essential for precise mitotic progression during early embryogenesis. Emi1(-/-) embryos were found to be lethal due to a defect in preimplantation development. Cell proliferation appeared to be normal, but mitotic progression was severely defective during embryonic cleavage. Moreover, multipolar spindles and misaligned chromosomes were frequently observed in Emi1 mutant cells, possibly due to premature APC activation. Our results collectively suggest that the late prophase checkpoint function of Emi1 is essential for accurate mitotic progression and embryonic viability. | - |
dc.description.sponsorship | This study was supported by the National Research Laboratory Program, the Korea National Cancer Center Control Program (0320370-1 and 0510582-2), and the 21st Century Frontier Functional Human Genome Project of KISTEP (Ministry of Science and Technology of Korea). | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | AMER SOC MICROBIOLOGY | - |
dc.subject | ANAPHASE-PROMOTING COMPLEX | - |
dc.subject | TUMOR-SUPPRESSOR RASSF1A | - |
dc.subject | CYTOSTATIC FACTOR ARREST | - |
dc.subject | POLO-LIKE KINASE | - |
dc.subject | SPINDLE CHECKPOINT | - |
dc.subject | CELL-CYCLE | - |
dc.subject | BETA-CATENIN | - |
dc.subject | PROTEIN | - |
dc.subject | MITOSIS | - |
dc.subject | MICE | - |
dc.title | Mouse emi1 has an essential function in mitotic progression during early embryogenesis | - |
dc.type | Article | - |
dc.identifier.wosid | 000238918000015 | - |
dc.identifier.scopusid | 2-s2.0-33745850483 | - |
dc.type.rims | ART | - |
dc.citation.volume | 26 | - |
dc.citation.beginningpage | 5373 | - |
dc.citation.endingpage | 5381 | - |
dc.citation.publicationname | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.identifier.doi | 10.1128/MCB.00043-06 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Lim, Dae-Sik | - |
dc.contributor.nonIdAuthor | Lee, Ho | - |
dc.contributor.nonIdAuthor | Lee, Dong Jun | - |
dc.contributor.nonIdAuthor | Oh, Sang Phil | - |
dc.contributor.nonIdAuthor | Park, Hee Dong | - |
dc.contributor.nonIdAuthor | Park, Hee Dong | - |
dc.contributor.nonIdAuthor | Nam, Hyun Hee | - |
dc.contributor.nonIdAuthor | Kim, Jin Man | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ANAPHASE-PROMOTING COMPLEX | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR RASSF1A | - |
dc.subject.keywordPlus | CYTOSTATIC FACTOR ARREST | - |
dc.subject.keywordPlus | POLO-LIKE KINASE | - |
dc.subject.keywordPlus | SPINDLE CHECKPOINT | - |
dc.subject.keywordPlus | CELL-CYCLE | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | MITOSIS | - |
dc.subject.keywordPlus | MICE | - |
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