DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Shim, Sang-Chul | - |
dc.contributor.advisor | 심상철 | - |
dc.contributor.author | Kim, Sung-Ki | - |
dc.contributor.author | 김성기 | - |
dc.date.accessioned | 2011-12-13T05:01:12Z | - |
dc.date.available | 2011-12-13T05:01:12Z | - |
dc.date.issued | 1997 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=112775&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/32755 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 화학과, 1997.2, [ v, 44 p. ] | - |
dc.description.abstract | The limiting factors in clinical use of photochemotherapeutic psoralens, 8-MOP, 5-MOP and TMP, are the poor water solubility and low intercalating efficiency with pyrimidine base pairs in DNA. Several psoralen derivatives ($Ps-O-C_3NH_2,Ps-O-Glu$, $Bis(PIP)C_4Ps$, $Bis(PIP)C_6Ps$, $Bis(PIP)C_8Ps$), which are expected to have high reactivity and water solubility, were synthesized and investigated the solubility and photochemical inactivation of PCR by these compounds. The solubility of psoralen derivatives is in the order of Ps-O-Glu > $Ps-O-C_3NH_2$ > 8-MOP > $Bis(PIP)C_4Ps$ > $Bis(PIP)C_6Ps$ > $Bis(PIP)C_8Ps$. The order of hypochromism effect (%H) is in the order of $Bis(PIP)C_6Ps $Bis(PIP)C_4Ps$ > $Bis(PIP)C_8Ps$. %H decreased according to the increase of alkyl chain length connecting psoralens. $Bis(PIP)C_4Ps$ and $Bis(PIP)C_6Ps$ were intercalated more effectively than 8-MOP between pyrimidine base pairs in DNA. Some psoralen derivatives synthesized showed better inactivation of PCR reaction than 8-methoxypsoralen. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | PCR | - |
dc.subject | Psoralen derivatives | - |
dc.subject | 소랄렌 유도체 | - |
dc.subject | PCR | - |
dc.title | Photochemical inactivation of PCR by psoralen derivatives | - |
dc.title.alternative | 소랄렌 유도체에 의한 PCR의 광화학적 불활성화 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 112775/325007 | - |
dc.description.department | 한국과학기술원 : 화학과, | - |
dc.identifier.uid | 000953069 | - |
dc.contributor.localauthor | Shim, Sang-Chul | - |
dc.contributor.localauthor | 심상철 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.