DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Kim, Yong-Hae | - |
dc.contributor.advisor | 김용해 | - |
dc.contributor.author | Lee, Chun-Ho | - |
dc.contributor.author | 이춘호 | - |
dc.date.accessioned | 2011-12-13T04:57:38Z | - |
dc.date.available | 2011-12-13T04:57:38Z | - |
dc.date.issued | 1988 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=66052&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/32515 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 화학과, 1988.2, [ vii, 55 p. ] | - |
dc.description.abstract | Purine and pyrimidine derivatives containing a tetrahydrofuran moiety were successfully synthesized by a condensation of 2-acetoxytetrahydrofuran and trimethylsilyl derivatives of purine or pyrimidine in the presence of catalytic amounts of cecium chloride in excellent yields. 9-(Tetrahydro-2-furyl) adenine and 1-(tetrahydro-2-furyl)-5-fluorouracil which are known to show antitumor activity as one of important cancer therapeutic agents were prepared by this method in excellent yields more than 90\%. The yields of tetrahydro-2-furyl nuclosidesof purine and pyrimidine derivatives are much higher than those from the known methods. Though the role of cesium chloride is not yet clear, it may be assumed that oxygen of ether oxygen to promote the carbonium electrophilicity at the carbon adjacent to the ether oxygen. Ceicum chloride appears to be promising catalyst for the condensation reaction. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.title | Synthesis of purine and pyrimidine derivatives using CsCl catalyst and by deamination | - |
dc.title.alternative | 염화세슘 촉매와 탈아미노화를 이용한 퓨린 및 피리미딘 유도체의 합성 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 66052/325007 | - |
dc.description.department | 한국과학기술원 : 화학과, | - |
dc.identifier.uid | 000861349 | - |
dc.contributor.localauthor | Kim, Yong-Hae | - |
dc.contributor.localauthor | 김용해 | - |
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