DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Lim, Hong | - |
dc.contributor.advisor | 임홍 | - |
dc.contributor.author | Cho, Yong-Seo | - |
dc.contributor.author | 조용서 | - |
dc.date.accessioned | 2011-12-13T04:57:17Z | - |
dc.date.available | 2011-12-13T04:57:17Z | - |
dc.date.issued | 1987 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=65529&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/32492 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 화학과, 1987.2, [ ii, 50 p. ] | - |
dc.description.abstract | Intermediate 3, a degradation product of a new indolizidine alkaloid Vincetene (1), was synthesized in optically pure form. Optically pure glutamate was coupled with 2,3-dimethoxynaphthalene and then cyclized to give pyroglutamate 18. Intramolecular Fridel-Crafts acylation of pyroglutamate 19 with tin tetrachloride in methylene chloride gave amido ketone 21 to the desired α-position of naphthalene ring. Reduction of ketone 21 with L-Selectride followed by deoxygenation of the resulting alcohol 22 produced amide 23 in high yield. Amide 23 was further reduced with lithium aluminum hydride to give the target compound 3 as a white crystalline solid. All the physical and spectral data (except optical rotation) of 3 was identical with those reported in the literature. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.title | Synthesis of an optically pure indolizidine derivative | - |
dc.title.alternative | 광학활성 인돌리지딘 유도체의 합성 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 65529/325007 | - |
dc.description.department | 한국과학기술원 : 화학과, | - |
dc.identifier.uid | 000851520 | - |
dc.contributor.localauthor | Lim, Hong | - |
dc.contributor.localauthor | 임홍 | - |
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