DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Ryu, Eung-Kul | - |
dc.contributor.advisor | 유응걸 | - |
dc.contributor.author | Kim, Jae-Nyoung | - |
dc.contributor.author | 김재녕 | - |
dc.date.accessioned | 2011-12-13T04:56:38Z | - |
dc.date.available | 2011-12-13T04:56:38Z | - |
dc.date.issued | 1986 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=64966&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/32447 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 화학과, 1986.2, [ [v], 43 p. ] | - |
dc.description.abstract | Four nucleic acid bases and their nucleosides were chlorinated by acyl chloride in dimethylformamide and m-chloroperbenzoic acid(MCPBA). The reaction of bases or nucleosides with MCPBA and acyl chlorides in dimethylformamide shows that under such conditions N-oxidation and chlorination of the primary hydroxyl group was not observed and the major product obtained was from the chlorination of heterocyclic bases. In the absence of MCPBA, the reaction took place the chlorination of 5``-hydroxy group of nucleosides. In the pyrimidine series, the product was the 5-chlorinated derivative and in the purine series, the 8-chlorinated analog was formed. In addition, other halide ion sources that could make complexes with dimethylformamide were investigated. 5-Bromouridine was also synthesized by using phosphorous tribromide in analogous manner. The halogenated compounds thus obtained were all separated by using silica gel column except for the 5-chlorouracil, and their structures or purities were characterized by the physical (mp, TLC) and spectroscopic (UV, NMR, HPLC) methods. Application and limitation of the chlorination reaction is discussed as well as mechanistic implications. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.title | New procedure for the chlorination of nucleic acid bases and their nucleosides | - |
dc.title.alternative | 핵산 염기와 뉴클레오시드의 새로운 염소화 반응에 관한 연구 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 64966/325007 | - |
dc.description.department | 한국과학기술원 : 화학과, | - |
dc.identifier.uid | 000841524 | - |
dc.contributor.localauthor | Ryu, Eung-Kul | - |
dc.contributor.localauthor | 유응걸 | - |
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