DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Kim, Yong-Hae | - |
dc.contributor.advisor | 김용해 | - |
dc.contributor.author | Kim, Hyoung-Rae | - |
dc.contributor.author | 김형래 | - |
dc.date.accessioned | 2011-12-13T04:55:34Z | - |
dc.date.available | 2011-12-13T04:55:34Z | - |
dc.date.issued | 1984 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=63963&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/32374 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 화학과, 1984.2, [ v, 49, [5] p. ] | - |
dc.description.abstract | 4,4,6-Trisubstituted-1,2,3,4,-tetrahydropyrimidin-2-thione derivatives were smoothly synthesized by the reaction of thiourea with α,β-unsaturated ketones in good yields under the mild conditions. The 2-thiotetrahydropyrimidines were S-methylated by methyl iodide in tetrahydrofuran to the corresponding 2-methylthio-3,4-dihydropyrimidine hydroiodides which were easily freed by alkyl amines. In order to compare the structure of the compound which was postulated to be 3,4,4,6-tetramethyl-2-amino-3,4-dihydropyrimidine, synthesized from methylguanidine and mesityl oxide, 4,4,6-trimethyl-2-methylthio-3,4-dihydropyrimidine hydroiodide was reacted with methylamine in pyridine. 2-Methylthio group was smoothly substituted by methylamine to 4,4,6-trimethyl-2-methylamino-3,4-dihydropyrimidine hydroiodide, which was identical with hydroiodide salt of the compound postulated previously to be 3,4,4,6-tetramethyl-2-amino 3,4-dihydropyrimidine. The biological activities of the compounds synthesized are being tested. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.title | Synthesis and characterization of dihydropyrimidine derivatives | - |
dc.title.alternative | 디하이드로 피리미딘 유도체합성 및 구조결정 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 63963/325007 | - |
dc.description.department | 한국과학기술원 : 화학과, | - |
dc.identifier.uid | 000821089 | - |
dc.contributor.localauthor | Kim, Yong-Hae | - |
dc.contributor.localauthor | 김용해 | - |
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