DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yi, Yelim | ko |
dc.contributor.author | Lee, Jimin | ko |
dc.contributor.author | Lim, Mi Hee | ko |
dc.date.accessioned | 2024-08-28T02:00:08Z | - |
dc.date.available | 2024-08-28T02:00:08Z | - |
dc.date.created | 2024-03-14 | - |
dc.date.issued | 2024-03 | - |
dc.identifier.citation | TRENDS IN CHEMISTRY, v.6, no.3, pp.128 - 143 | - |
dc.identifier.issn | 2589-5974 | - |
dc.identifier.uri | http://hdl.handle.net/10203/322442 | - |
dc.description.abstract | The accumulation of amyloid-beta (A beta) aggregates, a distinct pathological feature in Alzheimer's disease (AD), prompts exploration into mechanisms for A beta clearance from cerebral milieus. Notably, the efflux of A beta into peripheral fluids, encompassing the blood, cerebrospinal fluid (CSF), and lymph, emerges as a pivotal facet in its clearance. On its liberation from the cerebral realm, A beta engages in interactions with peripheral proteins, exerting profound effects on its assembly and toxicity. This interplay extends to A beta's transportation to peripheral tissues and organs, responsible for its degradation and excretion. This review illustrates the intricate transfer pathways of A beta from the brain to peripheral fluids and its interactions with peripheral proteins that can impact its aggregation and toxicity profiles associated with the pathogenesis of AD. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | Amyloid- β- interacting proteins in peripheral fl uids of Alzheimer's disease | - |
dc.type | Article | - |
dc.identifier.wosid | 001225805300001 | - |
dc.identifier.scopusid | 2-s2.0-85185597985 | - |
dc.type.rims | ART | - |
dc.citation.volume | 6 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 128 | - |
dc.citation.endingpage | 143 | - |
dc.citation.publicationname | TRENDS IN CHEMISTRY | - |
dc.identifier.doi | 10.1016/j.trechm.2024.01.003 | - |
dc.contributor.localauthor | Lim, Mi Hee | - |
dc.contributor.nonIdAuthor | Yi, Yelim | - |
dc.contributor.nonIdAuthor | Lee, Jimin | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Review | - |
dc.subject.keywordPlus | HUMAN SERUM-ALBUMIN | - |
dc.subject.keywordPlus | A-BETA | - |
dc.subject.keywordPlus | APOLIPOPROTEIN-E | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | TRANSTHYRETIN | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | FIBRINOGEN | - |
dc.subject.keywordPlus | FIBRILS | - |
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