DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bang, Yeong Hak | ko |
dc.contributor.author | Lee, Choong-kun | ko |
dc.contributor.author | Bang, Kyunghye | ko |
dc.contributor.author | Kim, Hyung-Don | ko |
dc.contributor.author | Kim, Kyu-pyo | ko |
dc.contributor.author | Jeong, Jae Ho | ko |
dc.contributor.author | Park, Inkeun | ko |
dc.contributor.author | Ryoo, Baek-Yeol | ko |
dc.contributor.author | Lee, Dong Ki | ko |
dc.contributor.author | Choi, Hye Jin | ko |
dc.contributor.author | Chung, Taek | ko |
dc.contributor.author | Jeon, Seung Hyuck | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.contributor.author | Oum, Chiyoon | ko |
dc.contributor.author | Kim, Seulki | ko |
dc.contributor.author | Lim, Yoojoo | ko |
dc.contributor.author | Park, Gahee | ko |
dc.contributor.author | Ahn, Chang Ho | ko |
dc.contributor.author | Lee, Taebum | ko |
dc.contributor.author | Finn, Richard S. | ko |
dc.contributor.author | Ock, Chan-Young | ko |
dc.contributor.author | Shin, Jinho | ko |
dc.contributor.author | Yoo, Changhoon | ko |
dc.date.accessioned | 2024-08-23T01:00:06Z | - |
dc.date.available | 2024-08-23T01:00:06Z | - |
dc.date.created | 2024-08-23 | - |
dc.date.issued | 2024-08 | - |
dc.identifier.citation | Clinical Cancer Research | - |
dc.identifier.issn | 1078-0432 | - |
dc.identifier.uri | http://hdl.handle.net/10203/322393 | - |
dc.description.abstract | <jats:title>Abstract</jats:title> <jats:p>Purpose: Anti-PD-1/L1 has been demonstrated for its efficacy when combined with cytotoxic chemotherapy in randomized phase 3 trials for advanced biliary tract cancer (BTC). However, no biomarker predictive of benefit has been established for anti-PD-1/L1 in BTC. Here, we evaluated tumor-infiltrating lymphocytes (TILs) using artificial intelligence-powered immune phenotype (AI-IP) analysis in advanced BTC treated with anti-PD-1. Patients and Methods: Pre-treatment H&amp;E-stained whole-slide images from 339 advanced BTC patients who received anti-PD-1 as second-line treatment or beyond, were utilized for AI-IP analysis and correlative analysis between AI-IP and efficacy outcomes with anti-PD-1. Next, data and images of BTC cohort from The Cancer Genome Atlas (TCGA) were additionally analyzed to evaluate the transcriptomic and mutational characteristics of various AI-IPs in BTC. Results: Overall, AI-IPs were classified as inflamed (high intratumoral TIL [iTIL]) in 40 patients (11.8%), immune-excluded (low iTIL and high stromal TIL) in 167 (49.3%), and immune-deserted (low TIL overall) in 132 (38.9%). The inflamed IP group showed a significantly higher overall response rate compared to the non-inflamed IP groups (27.5% vs. 7.7%, P&amp;lt;0.001). Median overall survival and progression-free survival were significantly longer in the inflamed IP group than in the non-inflamed IP group (OS: 12.6 vs. 5.1 months, P=0.002; PFS: 4.5 vs. 1.9 months, P&amp;lt;0.001). In the analysis using TCGA cohort, the inflamed IP showed increased cytolytic activity scores and an interferon-gamma signature compared to the non-inflamed IP. Conclusions: AI-powered IP based on spatial TIL analysis was effective in predicting the efficacy outcomes in patients with BTC treated with anti-PD-1.</jats:p> | - |
dc.language | English | - |
dc.publisher | American Association for Cancer Research (AACR) | - |
dc.title | Artificial intelligence-powered spatial analysis of tumor-infiltrating lymphocytes as a predictive biomarker for immune checkpoint inhibitors in biliary tract cancer | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.citation.publicationname | Clinical Cancer Research | - |
dc.identifier.doi | 10.1158/1078-0432.ccr-24-1265 | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Bang, Yeong Hak | - |
dc.contributor.nonIdAuthor | Lee, Choong-kun | - |
dc.contributor.nonIdAuthor | Bang, Kyunghye | - |
dc.contributor.nonIdAuthor | Kim, Hyung-Don | - |
dc.contributor.nonIdAuthor | Kim, Kyu-pyo | - |
dc.contributor.nonIdAuthor | Jeong, Jae Ho | - |
dc.contributor.nonIdAuthor | Park, Inkeun | - |
dc.contributor.nonIdAuthor | Ryoo, Baek-Yeol | - |
dc.contributor.nonIdAuthor | Lee, Dong Ki | - |
dc.contributor.nonIdAuthor | Choi, Hye Jin | - |
dc.contributor.nonIdAuthor | Chung, Taek | - |
dc.contributor.nonIdAuthor | Jeon, Seung Hyuck | - |
dc.contributor.nonIdAuthor | Oum, Chiyoon | - |
dc.contributor.nonIdAuthor | Kim, Seulki | - |
dc.contributor.nonIdAuthor | Lim, Yoojoo | - |
dc.contributor.nonIdAuthor | Park, Gahee | - |
dc.contributor.nonIdAuthor | Ahn, Chang Ho | - |
dc.contributor.nonIdAuthor | Lee, Taebum | - |
dc.contributor.nonIdAuthor | Finn, Richard S. | - |
dc.contributor.nonIdAuthor | Ock, Chan-Young | - |
dc.contributor.nonIdAuthor | Shin, Jinho | - |
dc.contributor.nonIdAuthor | Yoo, Changhoon | - |
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