DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 이정호 | - |
dc.contributor.author | Park, Jung Won | - |
dc.contributor.author | 박정원 | - |
dc.date.accessioned | 2024-08-08T19:31:29Z | - |
dc.date.available | 2024-08-08T19:31:29Z | - |
dc.date.issued | 2024 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=1099370&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/322122 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 의과학대학원, 2024.2,[iii, 73 p. :] | - |
dc.description.abstract | Discovering the cell of origin in brain tumors is challenging but important for fundamental basis of understanding the cancer-evolutionary process from beginning to terminal. Here, I identify the originating cell in human isocitrate dehydrogenase (IDH)-mutant glioma including astrocytoma and oligodendroglioma. I reveal that oligodendrocyte lineage cells containing oligodendrocyte progenitor cells (OPCs) and/or other glial cells harboring ultra-low-level of IDH1 alteration (> 0.115% of mutational burden) can be found in tumor-adjacent normal cortex in 62 patients with IDH-mutant glioma or other types of brain disease. As a biologic validation, OPC-specific somatic mutation mouse model exhibits hyperproliferative feature in mutant cells. Together, my results show that glial progenitor cell (GPC) as well as OPC that contain the IDH1 mutation are the cell of origin in IDH-mutant glioma. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | IDH-돌연변이 신경교종▼a기원세포▼a초저빈도 체성 돌연변이▼a교세포 전구세포▼a희소돌기아교세포 전구세포 | - |
dc.subject | IDH-mutant glioma▼aCell of origin▼aUltra-low-level somatic mutation▼aGlial progenitor cell▼aOligodendrocyte progenitor cell | - |
dc.title | Dissecting the cell of origin in IDH-mutant glioma | - |
dc.title.alternative | IDH-돌연변이 신경교종의 기원세포에 대한 고찰 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :의과학대학원, | - |
dc.contributor.alternativeauthor | Lee, Jeong Ho | - |
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