Investigations on hypothalamic mechanisms for the increased appetite by orexin오렉신에 의한 식욕 증가의 시상하부 기전 연구

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dc.contributor.advisor손종우-
dc.contributor.authorChoi, Jeewon-
dc.contributor.author최지원-
dc.date.accessioned2024-08-08T19:31:11Z-
dc.date.available2024-08-08T19:31:11Z-
dc.date.issued2024-
dc.identifier.urihttp://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=1099253&flag=dissertationen_US
dc.identifier.urihttp://hdl.handle.net/10203/322041-
dc.description학위논문(박사) - 한국과학기술원 : 생명과학과, 2024.2,[iii, 61 p. :]-
dc.description.abstractThe neuropeptide orexin (or hypocretin) plays a key role in the regulation of wakefulness and appetite. Although there has been thorough research on the neurocircuitry associated with orexin-induced wakefulness, our understanding of the regarding neurons responsible for orexin-induced feeding remains incomplete. In this study, I found that orexin A directly activates the “appetite-suppressing” pro-opiomelanocortin (POMC) neurons within the arcuate nucleus of the hypothalamus to promote food intake. Employing various methods such as patch-clamp electrophysiology, immunohistochemistry, and in vivo feeding studies, we investigated the neuronal circuits underlying the orexigenic effects of orexin. I discovered evidence that orexin A causes the depolarization of the membrane potential of POMC neurons via the hypocretin receptor 2 (HcrtR2)-phospholipase C $\beta 4$ ($PLC \beta 4$) signaling pathway. Notably, my findings revealed that HcrtR2 and $PLC \beta 4$ expressed by POMC neurons is sufficient and necessary, respectively, for orexin A-induced feeding. Furthermore, the central opioid system is activated downstream of POMC neurons to increase food intake by orexin A. Together, this study uncovered the identity of the first-order neuron by which orexin promotes feeding.-
dc.languageeng-
dc.publisher한국과학기술원-
dc.subject오렉신▼a시상하부▼aPOMC 뉴런▼a패치 클램프▼a식욕▼a오피오이드 시스템-
dc.subjectOrexin▼aHypothalamus▼aPOMC neurons▼aPatch clamp▼aappetite▼aopioid system-
dc.titleInvestigations on hypothalamic mechanisms for the increased appetite by orexin-
dc.title.alternative오렉신에 의한 식욕 증가의 시상하부 기전 연구-
dc.typeThesis(Ph.D)-
dc.identifier.CNRN325007-
dc.description.department한국과학기술원 :생명과학과,-
dc.contributor.alternativeauthorSohn, Jong-Woo-
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