DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Wonsik | ko |
dc.contributor.author | Asaduddin, Muhammad | ko |
dc.contributor.author | Yoo, Dohyun | ko |
dc.contributor.author | Lee, Dong Yun | ko |
dc.contributor.author | Son, Youngju | ko |
dc.contributor.author | Kim, Dohyeon | ko |
dc.contributor.author | Keum, Hyeongseop | ko |
dc.contributor.author | Lee, Jungun | ko |
dc.contributor.author | Park, Sung-Hong | ko |
dc.contributor.author | Jon, Sangyong | ko |
dc.date.accessioned | 2024-08-05T09:00:06Z | - |
dc.date.available | 2024-08-05T09:00:06Z | - |
dc.date.created | 2024-08-05 | - |
dc.date.created | 2024-08-05 | - |
dc.date.issued | 2024-10 | - |
dc.identifier.citation | BIOMATERIALS, v.310 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | http://hdl.handle.net/10203/321718 | - |
dc.description.abstract | Reactive oxygen species (ROS) that are overproduced in certain tumors can be considered an indicator of oxidative stress levels in the tissue. Here, we report a magnetic resonance imaging (MRI)-based probe capable of detecting ROS levels in the tumor microenvironment (TME) using ROS-responsive manganese ion (Mn2+)chelated, biotinylated bilirubin nanoparticles (Mn@bt-BRNPs). These nanoparticles are disrupted in the presence of ROS, resulting in the release of free Mn2+, which induces T1-weighted MRI signal enhancement. Mn@BRNPs show more rapid and greater MRI signal enhancement in high ROS-producing A549 lung carcinoma cells compared with low ROS-producing DU145 prostate cancer cells. A pseudo three-compartment model devised for the ROS-reactive MRI probe enables mapping of the distribution and concentration of ROS within the tumor. Furthermore, doxorubicin-loaded, cancer-targeting ligand biotin-conjugated Dox/Mn@bt-BRNPs show considerable accumulation in A549 tumors and also effectively inhibit tumor growth without causing body weight loss, suggesting their usefulness as a new theranostic agent. Collectively, these findings suggest that Mn@bt-BRNPs could be used as an imaging probe capable of detecting ROS levels and monitoring drug delivery in the TME with potential applicability to other inflammatory diseases. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Noninvasive ROS imaging and drug delivery monitoring in the tumor microenvironment | - |
dc.type | Article | - |
dc.identifier.wosid | 001246650700001 | - |
dc.identifier.scopusid | 2-s2.0-85194078001 | - |
dc.type.rims | ART | - |
dc.citation.volume | 310 | - |
dc.citation.publicationname | BIOMATERIALS | - |
dc.identifier.doi | 10.1016/j.biomaterials.2024.122633 | - |
dc.contributor.localauthor | Park, Sung-Hong | - |
dc.contributor.localauthor | Jon, Sangyong | - |
dc.contributor.nonIdAuthor | Jung, Wonsik | - |
dc.contributor.nonIdAuthor | Asaduddin, Muhammad | - |
dc.contributor.nonIdAuthor | Yoo, Dohyun | - |
dc.contributor.nonIdAuthor | Lee, Dong Yun | - |
dc.contributor.nonIdAuthor | Son, Youngju | - |
dc.contributor.nonIdAuthor | Kim, Dohyeon | - |
dc.contributor.nonIdAuthor | Keum, Hyeongseop | - |
dc.contributor.nonIdAuthor | Lee, Jungun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Bilirubin nanoparticles | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
dc.subject.keywordAuthor | MRI contrast agents | - |
dc.subject.keywordAuthor | A pseudo three -compartment model | - |
dc.subject.keywordAuthor | Tumor microenvironment | - |
dc.subject.keywordPlus | BILIRUBIN NANOPARTICLESREACTIVE OXYGENHYDROGEN-PEROXIDEOXIDATIVE STRESSNANOMEDICINEINFLAMMATIONPROGRESSIONMETABOLISMBIOMARKERMNDPDP | - |
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